ArticlePLoS genetics2020
Additive and mostly adaptive plastic responses of gene expression to multiple stress in Tribolium castaneum.
Article in PLoS genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 45 citations in OpenAlex.
- Network Properties Influence Covariance Between Gene Expression and Fecundity Fitness of Caenorhabditis elegans in a Novel Laboratory Environment.Genome biology and evolution · 2026Article
- Gene expression evolution is predicted by stronger indirect selection at more pleiotropic genes.Evolution letters · 2025Article
- Selection on genome-wide gene expression plasticity of rice in wet and dry field environments.Molecular ecology · 2025Article
- Nonlinear transcriptomic responses to compounded environmental changes across temperature and resources in a pest beetle, Callosobruchus maculatus (Coleoptera: Chrysomelidae).Journal of insect science (Online) · 2024Article
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- Sexual conflict, heterochrony and tissue specificity as evolutionary problems of adaptive plasticity in development.Proceedings. Biological sciences · 2023Review
- Identification of genes associated with abiotic stress tolerance in sweetpotato using weighted gene co-expression network analysis.Plant direct · 2023Article
- Transcriptomic analysis reveals the rareness of genetic assimilation of gene expression in environmental adaptations.Science advances · 2023Article
- Understanding and applying biological resilience, from genes to ecosystems.npj biodiversity · 2023Review
- Sexual selection moderates heat stress response in males and females.Functional ecology · 2022Article
- Using phenotypic plasticity to understand the structure and evolution of the genotype-phenotype map.Genetica · 2022Review
- Adaptation and correlated fitness responses over two time scales in Drosophila suzukii populations evolving in different environments.Journal of evolutionary biology · 2021Article
- Chitosan Coating Enriched WithFrontiers in plant science · 2021Article
- Experimental evolution of immunological specificity.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene expression is known to be highly responsive to the environment and important for adjustment of metabolism but there is also growing evidence that differences in gene regulation contribute to species divergence and differences among locally adapted populations. However, most studies so far investigated populations when divergence had already occurred. Selection acting on expression levels at the onset of adaptation to an environmental change has not been characterized. Understanding the mechanisms is further complicated by the fact that environmental change is often multivariate, meaning that organisms are exposed to multiple stressors simultaneously with potentially interactive effects. Here we use a novel approach by combining fitness and whole-transcriptome data in a large-scale experiment to investigate responses to drought, heat and their combination in Tribolium castaneum. We found that fitness was reduced by both stressors and their combined effect was almost additive. Expression data showed that stressor responses were acting independently and did not interfere physiologically. Since we measured expression and fitness within the same individuals, we were able to estimate selection on gene expression levels. We found that variation in fitness can be attributed to gene expression variation and that selection pressures were environment dependent and opposite between control and stress conditions. We could further show that plastic responses of expression were largely adaptive, i.e. in the direction that should increase fitness.
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