Evidence map›Paper›PMID 32379598›Full record

ArticleCanadian Urological Association journal = Journal de l'Association des urologues du Canada2020

Economic evaluation of robot-assisted radical prostatectomy compared to open radical prostatectomy for prostate cancer treatment in Ontario, Canada.

Anna Parackal, Jean-Eric Tarride, Feng Xie, Gord Blackhouse, Jen Hoogenes, Danielle Hylton, Wael Hanna, Anthony Adili, Edward D Matsumoto, Bobby Shayegan

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 22 citations in OpenAlex.

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  16. Robotic thoracic surgery in Canada: Are patients willing to pay out of pocket?Canadian journal of surgery. Journal canadien de chirurgie
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Anna ParackalDepartment of Health Research Methods, Evidence & Impact (HEI), McMaster University, Hamilton, ON, Canada.
Jean-Eric TarrideDepartment of Health Research Methods, Evidence & Impact (HEI), McMaster University, Hamilton, ON, Canada.
Feng XieDepartment of Health Research Methods, Evidence & Impact (HEI), McMaster University, Hamilton, ON, Canada.
Gord BlackhouseDepartment of Health Research Methods, Evidence & Impact (HEI), McMaster University, Hamilton, ON, Canada.
Jen HoogenesDepartment of Surgery, McMaster University, Hamilton, ON, Canada.
Danielle HyltonDepartment of Health Research Methods, Evidence & Impact (HEI), McMaster University, Hamilton, ON, Canada.
Wael HannaDepartment of Health Research Methods, Evidence & Impact (HEI), McMaster University, Hamilton, ON, Canada.
Anthony AdiliDepartment of Surgery, McMaster University, Hamilton, ON, Canada.
Edward D MatsumotoDepartment of Surgery, McMaster University, Hamilton, ON, Canada.
Bobby ShayeganDepartment of Surgery, McMaster University, Hamilton, ON, Canada.
McMaster University · CAImpact · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionRecent health technology assessments (HTAs) of robot-assisted radical prostatectomy (RARP) in Ontario and Alberta, Canada, resulted in opposite recommendations, calling into question whether benefits of RARP offset the upfront investment. Therefore, the study objectives were to conduct a cost-utility analysis from a Canadian public payer perspective to determine the cost-effectiveness of RARP.

methodsUsing a 10-year time horizon, a five-state Markov model was developed to compare RARP to open radical prostatectomy (ORP). Clinical parameters were derived from Canadian observational studies and a recently published systematic review. Costs, resource utilization, and utility values from recent Canadian sources were used to populate the model. Results were presented in terms of increment costs per quality-adjusted life years (QALYs) gained. A probabilistic analysis was conducted, and uncertainty was represented using cost-effectiveness acceptability curves (CEACs). One-way sensitivity analyses were also conducted. Future costs and QALYs were discounted at 1.5%.

resultsTotal cost of RARP and ORP were $47 033 and $45 332, respectively. Total estimated QALYs were 7.2047 and 7.1385 for RARP and ORP, respectively. The estimated incremental cost-utility ratio (ICUR) was $25 704 in the base-case analysis. At a willingness-to-pay threshold of $50 000 and $100 000 per QALY gained, the probability of RARP being cost-effective was 0.65 and 0.85, respectively. The model was most sensitive to the time horizon.

conclusionsThe results of this analysis suggest that RARP is likely to be cost-effective in this Canadian patient population. The results are consistent with Alberta's HTA recommendation and other economic evaluations, but challenges Ontario's reimbursement decision.

Identifiers

PMID32379598
PMCPMC7402691
OpenAlexW3022924108

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.