Evidence map›Paper›PMID 32379591›Full record

ReviewCurrent neuropharmacology2021

Effects of Mulberry on The Central Nervous System: A Literature Review.

Dao Ngoc Hien Tam, Nguyen Hai Nam, Mohamed Tamer Elhady, Linh Tran, Osama Gamal Hassan, Mohamed Sadik, Phan Thi My Tien, Ghada Amr Elshafei, Nguyen Tien Huy

Open access · greenAbstract readReview
In one paragraph

Review in Current neuropharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Anti-Inflammatory and Anti-Bacterial Potential of Mulberry Leaf Extract on Oral Microorganisms.International journal of environmental research and public health · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Dao Ngoc Hien TamAsia Shine Trading & Service Co. LTD., Ho Chi Minh City, Vietnam.
Nguyen Hai NamDepartment of General Surgery, University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam.
Mohamed Tamer ElhadyPediatric Department, Zagazig University Hospital, Sharkia, Egypt.
Linh TranInstitute of Fundamental and Applied Sciences, Duy Tan University, Ho Chi Minh City 700000, Vietnam.
Osama Gamal HassanFaculty of Medicine, South Valley University, Qena, Egypt.
Mohamed SadikFaculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
Phan Thi My TienUniversity of Medicine and Pharmacy at Ho Chi Minh City, Japan.
Ghada Amr ElshafeiFaculty of Medicine, Cairo University, Egypt.
Nguyen Tien HuyEvidence Based Medicine Research Group, Ton Duc Thang University, Ho Chi Minh City, 700000, Vietnam.
Al-Azhar University · EGCairo University · EGDuy Tan University · VNHo Chi Minh City Medicine and Pharmacy University · VNSouth Valley University · EGTon Duc Thang University · VNZagazig University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMulberry, including several species belonging to genus Morus, has been widely used as a traditional medicine for a long time. Extracts and active components of mulberry have many positive neurological and biological effects and can become potential candidates in the search for new drugs for neurological disorders.

objectivesWe aimed to systematically review the medical literature for evidence of mulberry effects on the central nervous system.

methodsWe conducted a systematic search in nine databases. We included all in vivo studies investigating the effect of mulberry on the central nervous system with no restrictions.

resultsWe finally included 47 articles for quality synthesis. Our findings showed that mulberry and its components possessed an antioxidant effect, showed a reduction in the cerebral infarct volume after stroke. They also improved the cognitive function, learning process, and reduced memory impairment in many animal models. M. alba and its extracts ameliorated Parkinson's disease-like behaviors, limited the complications of diabetes mellitus on the central nervous system, possessed anti-convulsant, anti-depressive, and anxiolytic effects.

conclusionMulberry species proved beneficial to many neurological functions in animal models. The active ingredients of each species, especially M. alba, should be deeper studied for screening potential candidates for future treatments.

Indexed as

MorusAnimalsCentral Nervous SystemFruitPlant ExtractsPlant LeavesPlant Extractsantidepressionmemory improvementMorusMulberryneurologysystematic review

Identifiers

PMID32379591
PMCPMC8033976
OpenAlexW3023790937

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.