Evidence map›Paper›PMID 32379487›Full record

Trial reportCanadian journal of psychiatry. Revue canadienne de psychiatrie2020

A Randomized Sham-controlled Trial of 1-Hz and 10-Hz Repetitive Transcranial Magnetic Stimulation (rTMS) of the Right Dorsolateral Prefrontal Cortex in Civilian Post-traumatic Stress Disorder: Un essai randomisé contrôlé simulé de stimulation magnétique transcrânienne repetitive (SMTr) de 1 Hz et 10 Hz du cortex préfrontal dorsolatéral droit dans le trouble de stress post-traumatique chez des civils.

Kawai Leong, Peter Chan, Larry Ong, Amy Zwicker, Sharon Willan, Raymond W Lam, Alexander McGirr

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 4 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Observational
  18. Transcranial magnetic stimulation for post-traumatic stress disorder.Therapeutic advances in psychopharmacology · 2021
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Kawai LeongDepartment of Psychiatry, 8166University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0001-7495-0613
Peter ChanDepartment of Psychiatry, 8166University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0002-6450-4326
Larry OngDepartment of Psychiatry, 8166University of British Columbia, Vancouver, British Columbia, Canada.
Amy ZwickerDepartment of Psychiatry, 8166University of British Columbia, Vancouver, British Columbia, Canada.
Sharon Willan380154Vancouver General Hospital, British Columbia, Canada.
Raymond W LamDepartment of Psychiatry, 8166University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0001-7142-4669
Alexander McGirrDepartment of Psychiatry, 2129University of Calgary, Alberta, Canada.ORCID 0000-0002-8425-3958
University of British Columbia · CAUniversity of Calgary · CAVancouver General Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveDespite effective psychological and pharmacological treatments, there is a large unmet burden of illness in post-traumatic stress disorder (PTSD). Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive intervention and a putative treatment strategy for PTSD. The evidence base to date suggests that rTMS targeting the dorsolateral prefrontal cortex (DLPFC), in particular the right DLPFC, leads to improvements in PTSD symptoms. However, optimal stimulation parameters have yet to be determined. In this study, we examine the efficacy of high- and low-frequency rTMS of the right DLPFC using a randomized, double-blind, sham-controlled design in civilian PTSD.

methodsWe conducted a 2-week single-site randomized sham-controlled trial of rTMS targeting the right DLPFC. We recruited civilians aged 19 to 70 with PTSD and randomized subjects with allocation concealment to daily 1-Hz rTMS, 10-Hz rTMS, or sham rTMS. The primary outcome was improvement in Clinician Administered PTSD Scale-IV (CAPS-IV). Secondary outcomes included change in depressive and anxiety symptoms.

resultsWe recruited 31 civilians with PTSD. One 1-Hz-treated patient developed transient suicidal ideation. Analyses revealed significant improvement in CAPS-IV symptoms in the 1-Hz group relative to sham (Hedges'

conclusionLow-frequency rTMS is efficacious in the treatment of civilian PTSD. Our data suggest that high-frequency rTMS of the right DLPFC is worthy of additional investigation for the treatment of depressive symptoms comorbid with PTSD.

Indexed as

Stress Disorders, Post-TraumaticDouble-Blind MethodHumansPrefrontal CortexTranscranial Magnetic StimulationTreatment Outcomecivilian PTSDdepressionpost-traumatic stress disorderPTSDrandomized clinical trialRCTrepetitive transcranial magnetic stimulationrTMS

Identifiers

PMID32379487
PMCPMC7564694
OpenAlexW3022903298

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.