ArticleJournal of the American Chemical Society2020
Hydroarylation of Arenes via Reductive Radical-Polar Crossover.
Article in Journal of the American Chemical Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Dearomative syn-1,4-hydroalkylation and C(spNature chemistry · 2026Article
- Three-Way Chemodivergent Derivatization of Non-Activated 2-Arylphenyl Benzyl Ethers.The Journal of organic chemistry · 2025Article
- Visible light-mediated dearomative spirocyclization/imination of nonactivated arenes through energy transfer catalysis.Nature communications · 2025Article
- Radical-Dearomative Generation of Cyclohexadienyl Pd(II) toward the 3D Transformation of Nonactivated Phenyl Rings.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Gram-scale photosynthesis of polyfunctionalized dihydro-2-oxypyrroles using 3DPAFIPN as a halogenated dicyanobenzene-based photosensitizer via a consecutive visible-light-induced electron transfer process.Frontiers in chemistry · 2024Article
- Halogenated dicyanobenzene-based photosensitizer (3DPAFIPN) as a thermally activated delayed fluorescence (TADF) used in gram-scale photosynthesis 3,4-dihydropyrimidin-2-(1Frontiers in chemistry · 2024Article
- 3DPAFIPN as a halogenated dicyanobenzene-based photosensitizer catalyzed gram-scale photosynthesis of pyrano[2,3-d]pyrimidine scaffolds.Scientific reports · 2023Article
- Light-Induced Access to Carbazole-1,3-dicarbonitrile: A Thermally Activated Delayed Fluorescent (TADF) Photocatalyst for Cobalt-Mediated Allylations.The Journal of organic chemistry · 2023Article
- Photoredox catalysis harvesting multiple photon or electrochemical energies.Beilstein journal of organic chemistry · 2023Review
- Electrochemically-promoted synthesis of benzo[Chemical science · 2022Article
- Highly congested spiro-compounds via photoredox-mediated dearomative annulation cascade.Communications chemistry · 2022Article
- Divergent synthesis of benzazepines and bridged polycycloalkanones via dearomative rearrangement.Nature communications · 2022Article
- Rapid syntheses of N-fused heterocycles via acyl-transfer in heteroaryl ketones.Nature communications · 2022Article
- Radical boron migration of allylboronic esters.Chemical science · 2022Article
- Deacylation-Aided C─H Alkylative Annulation through C─C Cleavage of Unstrained Ketones.Nature catalysis · 2021Article
- Dearomatization through Photoredox Hydroarylation: Discovery of a Radical-Polar Crossover Strategy.Organic letters · 2021Article
- Defluorodearomatization: A Photocatalytic Birch-Like Reduction That Enables C-C Bond Formation and Provides Access to Unnatural Cannabinoids.The Journal of organic chemistry · 2021Article
- Dearomatization of Unactivated Arenes via Catalytic Hydroalkylation.ACS catalysis · 2021Article
- A Thiol-Mediated Three-Step Ring Expansion Cascade for the Conversion of Indoles into Functionalized Quinolines.Organic letters · 2021Article
- Synthesis of 6Organic letters · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
A photocatalytic system for the dearomative hydroarylation of benzene derivatives has been developed. Using a combination of an organic photoredox catalyst and an amine reductant, this process operates through a reductive radical-polar crossover mechanism where aryl halide reduction triggers a regioselective radical cyclization event, followed by anion formation and quenching to produce a range of complex spirocyclic cyclohexadienes. This light-driven protocol functions at room temperature in a green solvent system (aq. MeCN) without the need for precious metal-based catalysts or reagents or the generation of stoichiometric metal byproducts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.