ArticleHuman brain mapping2020
Probing regional cortical excitability via input-output properties using transcranial magnetic stimulation and electroencephalography coupling.
Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Methodological Choices Matter: A Systematic Comparison of TMS-EEG Studies Targeting the Primary Motor Cortex.Human brain mapping · 2024Pooled it
- Mechanisms of transcranial magnetic brain stimulation.Physiological reviews · 2026Review
- Clinical utility and prospective of TMS-EEG: Updated review from an international expert group.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Review
- Efficient Gaussian process-based motor hotspot hunting with concurrent optimization of TMS coil location and orientation.PLoS computational biology · 2026Article
- Investigating the effects of TMS-related somatosensory inputs on TMS-evoked potentials provides evidence against significant interaction.Scientific reports · 2026Article
- From Correlation to Causation: Understanding Episodic Memory Networks.Neuroscience bulletin · 2025Review
- Evoked EEG Responses to TMS Targeting Regions Outside the Primary Motor Cortex and Their Test-Retest Reliability.Brain topography · 2024Article
- A dose-response characterization of transcranial magnetic stimulation intensity and evoked potential amplitude in the dorsolateral prefrontal cortex.Scientific reports · 2023Article
- Article
- Reliability and Validity of Transcranial Magnetic Stimulation-Electroencephalography Biomarkers.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Review
- TMS-evoked EEG potentials demonstrate altered cortical excitability in migraine with aura.Brain topography · 2023Article
- The external evocation and movement-related modulation of motor cortex inhibition in children and adolescents with Tourette syndrome - a TMS/EEG study.Frontiers in neuroscience · 2023Article
- Multi-scale and cross-dimensional TMS mapping: A proof of principle in patients with Parkinson's disease and deep brain stimulation.Frontiers in neuroscience · 2023Article
- Using TMS-EEG to assess the effects of neuromodulation techniques: a narrative review.Frontiers in human neuroscience · 2023Review
- Toward individualized medicine in stroke-The TiMeS project: Protocol of longitudinal, multi-modal, multi-domain study in stroke.Frontiers in neurology · 2022Article
- Update Research Advances in the Application of Transcranial Magnetic Stimulation in the Treatment of Schizophrenia.Scanning · 2022Review
- Towards more reliable TMS studies - How fast can we probe cortical excitability?Clinical neurophysiology practice · 2022Article
- Recording brain responses to TMS of primary motor cortex by EEG - utility of an optimized sham procedure.NeuroImage · 2021Article
- Temporally-precise disruption of prefrontal cortex informed by the timing of beta bursts impairs human action-stopping.NeuroImage · 2020Article
- Probing regional cortical excitability via input-output properties using transcranial magnetic stimulation and electroencephalography coupling.Human brain mapping · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The modular organization of the cortex refers to subsets of highly interconnected nodes, sharing specific cytoarchitectural and dynamical properties. These properties condition the level of excitability of local pools of neurons. In this study, we described TMS evoked potentials (TEP) input-output properties to provide new insights into regional cortical excitability. We combined robotized TMS with EEG to disentangle region-specific TEP from threshold to saturation and describe their oscillatory contents. Twenty-two young healthy participants received robotized TMS pulses over the right primary motor cortex (M1), the right dorsolateral prefrontal cortex (DLPFC) and the right superior occipital lobe (SOL) at five stimulation intensities (40, 60, 80, 100, and 120% resting motor threshold) and one short-interval intracortical inhibition condition during EEG recordings. Ten additional subjects underwent the same experiment with a realistic sham TMS procedure. The results revealed interregional differences in the TEPs input-output functions as well as in the responses to paired-pulse conditioning protocols, when considering early local components (<80 ms). Each intensity in the three regions was associated with complex patterns of oscillatory activities. The quality of the regression of TEPs over stimulation intensity was used to derive a new readout for cortical excitability and dynamical properties, revealing lower excitability in the DLPFC, followed by SOL and M1. The realistic sham experiment confirmed that these early local components were not contaminated by multisensory stimulations. This study provides an entirely new analytic framework to characterize input-output relations throughout the cortex, paving the way to a more accurate definition of local cortical excitability.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.