Evidence map›Paper›PMID 32379325›Full record

ArticleNucleic acids research2020

GeneTrail 3: advanced high-throughput enrichment analysis.

Nico Gerstner, Tim Kehl, Kerstin Lenhof, Anne Müller, Carolin Mayer, Lea Eckhart, Nadja Liddy Grammes, Caroline Diener, Martin Hart, Oliver Hahn and 5 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  8. Construction and Analysis of miRNA Regulatory Networks.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
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  17. A Novel AMPK Inhibitor Sensitizes Pancreatic Cancer Cells to Ferroptosis Induction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  18. Article
  19. Article
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Nico GerstnerCenter for Bioinformatics, Saarland Informatics Campus, Saarland University, 66123 Saarbrücken, Germany.
Tim KehlCenter for Bioinformatics, Saarland Informatics Campus, Saarland University, 66123 Saarbrücken, Germany.
Kerstin LenhofCenter for Bioinformatics, Saarland Informatics Campus, Saarland University, 66123 Saarbrücken, Germany.
Anne MüllerCenter for Bioinformatics, Saarland Informatics Campus, Saarland University, 66123 Saarbrücken, Germany.
Carolin MayerCenter for Bioinformatics, Saarland Informatics Campus, Saarland University, 66123 Saarbrücken, Germany.
Lea EckhartCenter for Bioinformatics, Saarland Informatics Campus, Saarland University, 66123 Saarbrücken, Germany.
Nadja Liddy GrammesCenter for Bioinformatics, Saarland Informatics Campus, Saarland University, 66123 Saarbrücken, Germany.
Caroline DienerDepartment of Human Genetics, Saarland University, 66421 Homburg, Germany.
Martin HartDepartment of Human Genetics, Saarland University, 66421 Homburg, Germany.
Oliver HahnSchool of Medicine Office, Stanford University, Stanford, CA, USA.
Jörn WalterDepartment of Genetics, Saarland University, Saarbrücken D-66041, Germany.
Tony Wyss-CoraySchool of Medicine Office, Stanford University, Stanford, CA, USA.
Eckart MeeseDepartment of Human Genetics, Saarland University, 66421 Homburg, Germany.
Andreas KellerCenter for Bioinformatics, Saarland Informatics Campus, Saarland University, 66123 Saarbrücken, Germany.
Hans-Peter LenhofCenter for Bioinformatics, Saarland Informatics Campus, Saarland University, 66123 Saarbrücken, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present GeneTrail 3, a major extension of our web service GeneTrail that offers rich functionality for the identification, analysis, and visualization of deregulated biological processes. Our web service provides a comprehensive collection of biological processes and signaling pathways for 12 model organisms that can be analyzed with a powerful framework for enrichment and network analysis of transcriptomic, miRNomic, proteomic, and genomic data sets. Moreover, GeneTrail offers novel workflows for the analysis of epigenetic marks, time series experiments, and single cell data. We demonstrate the capabilities of our web service in two case-studies, which highlight that GeneTrail is well equipped for uncovering complex molecular mechanisms. GeneTrail is freely accessible at: http://genetrail.bioinf.uni-sb.de.

Indexed as

SoftwareAgingAnimalsCD4-Positive T-LymphocytesEpigenomicsGene Expression ProfilingGenomicsHumansLymphocyte ActivationMiceMicrogliaProteomicsSignal TransductionSingle-Cell Analysis

Identifiers

PMID32379325
PMCPMC7319559

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.