ArticlePain2020
Brain gray matter abnormalities in osteoarthritis pain: a cross-sectional evaluation.
Article in Pain, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Altered spontaneous brain activity in lumbar disc herniation patients: insights from an ALE meta-analysis of neuroimaging data.Frontiers in neuroscience · 2024Pooled it
- Neurobiology of osteoarthritis: a systematic review and activation likelihood estimation meta-analysis.Scientific reports · 2023Pooled it
- Effects of Tai Chi combined with transcranial direct current stimulation on pain in knee osteoarthritis: a randomized controlled neuroimaging trial.BMC medicine · 2026Trial
- Optimizing Chronic Pain Treatment with Enhanced Neuroplastic Responsiveness: A Pilot Randomized Controlled Trial.Nutrients · 2021Trial
- Neuro-immune interactions in tumors, immune-related disorders, and infections.Signal transduction and targeted therapy · 2026Review
- Multi-omics integration and clinical validation identify CKAP2 as a diagnostic biomarker for bladder cancer.World journal of surgical oncology · 2026Article
- Grey matter volume reduction in the cerebellum of hip osteoarthritis patients: insights from pre- and postoperative VBM analysis.La Radiologia medica · 2026Article
- Post-traumatic osteoarthritis in aged rodents is associated with brain changes that correlate with joint remodeling.The journal of pain · 2026Article
- The brain-gut-joint axis in arthritis: crosstalk, treatment, and future perspectives.Journal of orthopaedic translation · 2026Review
- Targeting Central Sensitization for Pain Management in Knee Osteoarthritis: A Narrative Review of Mechanisms and Clinical Applications of Neuromodulation.Journal of pain research · 2026Review
- Correlation between chronic pain, disability, and psychological factors (depression and anxiety) after surgery for acute orthopedic trauma.World journal of psychiatry · 2025Article
- Brain compensation and volume alterations in patients with severe knee osteoarthritis: a cross-sectional neuroimaging study.Rheumatology international · 2025Article
- The causal role of brain circuits in osteoarthritis pain.Nature reviews. Rheumatology · 2025Review
- Brain functional imaging contributions in osteoarthritis-related pain: A viewpoint.Osteoarthritis and cartilage open · 2025Article
- Efficacy and brain modulation mechanisms of acupuncture for chronic prostatitis/chronic pelvic pain syndrome revealed by structural MRI changes.Frontiers in neurology · 2025Article
- Impaired amygdala astrocytic signaling worsens neuropathic pain-associated neuronal functions and behaviors.Frontiers in pharmacology · 2024Article
- Identification of Specific Abnormal Brain Functional Activity and Connectivity in Cancer Pain Patients: A Preliminary Resting-State fMRI Study.Journal of pain research · 2024Article
- Association ofNeurology · 2023Article
- Detangling the Structural Neural Correlates Associated with Resting versus Dynamic Phantom Limb Pain Intensity Using a Voxel-based Morphometry Analysis.Pain medicine (Malden, Mass.) · 2023Article
- Pain in Huntington's disease and its potential mechanisms.Frontiers in aging neuroscience · 2023Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
abstractThe interaction between osteoarthritis (OA) pain and brain properties remains minimally understood, although anatomical and functional neuroimaging studies suggest that OA, similar to other chronic pain conditions, may impact as well as partly be determined by brain properties. Here, we studied brain gray matter (GM) properties in OA patients scheduled to undergo total joint replacement surgery. We tested the hypothesis that brain regional GM volume is distinct between hip OA (HOA) and knee OA (KOA) patients, relative to healthy controls and moreover, that these properties are related to OA pain. Voxel-based morphometry group contrasts showed lower anterior cingulate GM volume only in HOA. When we reoriented the brains (flipped) to examine the hemisphere contralateral to OA pain, precentral GM volume was lower in KOA and HOA, and 5 additional brain regions showed distortions between groups. These GM changes, however, did not reflect clinical parameters. Next, we subdivided the brain into larger regions, approximating Brodmann areas, and performed univariable and machine learning-based multivariable contrasts. The univariable analyses approximated voxel-based morphometry results. Our multivariable model distinguished between KOA and controls, was validated in a KOA hold-out sample, and generalized to HOA. The multivariable model in KOA, but not HOA, was related to neuropathic OA pain. These results were mapped into term space (using Neurosynth), providing a meta-analytic summary of brain anatomical distortions in OA. Our results indicate more subtle cortical anatomical differences in OA than previously reported and also emphasize the interaction between OA pain, namely its neuropathic component, and OA brain anatomy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.