Evidence map›Paper›PMID 32379201›Full record

Trial reportThe Pediatric infectious disease journal2020

Influenza or Meningococcal Immunization During Pregnancy and Mortality in Women and Infants: A Pooled Analysis of Randomized Controlled Trials.

Dayna R Clark, Saad B Omer, Milagritos D Tapia, Marta C Nunes, Clare L Cutland, James M Tielsch, Niteen Wairagkar, Shabir A Madhi, for BMGF Supported Maternal Influenza Immunization Trials Investigators Group

3 registry-linked trialsOpen access · hybridAbstract readClinical Trial, Phase IIIMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Pediatric infectious disease journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01034254 phase3completednot on this map

Field Trial of Maternal Influenza Immunization in Asia

TypeinterventionalSponsorChildren's Hospital Medical Center, CincinnatiRan2010 to 2017Enrolled3,693ConditionsInfluenza HumanArmsinfluenza vaccine, saline placebo
NCT01430689 phase4completednot on this map

Prospective, Randomized, Controlled, Observer-Blind Trial to Measure the Efficacy, Safety and Immunogenicity of Trivalent Inactivated Influenza Vaccine and the Safety and Immunogenicity of Quadrivalent Meningococcal Polysaccharide Diphtheria Conjugate Vaccine in Pregnant Malian Women and Their Infants up to 6 Months of Age

TypeinterventionalSponsorUniversity of Maryland, BaltimoreRan2011 to 2014Enrolled4,193ConditionsInfluenzaArmsInactivated Influenza Vaccine Trivalent Types A and B, Meningococcal Polysaccharide-Diphtheria Toxoid Conjugate Vaccine
NCT02465190 unknown statusnot on this map

Effectiveness of Trivalent Inactivated Influenza Maternal Vaccination Among Pregnant Women and Their Newborns in South Africa

Typeobservational_patient_registrySponsorNational Institute for Communicable Diseases, South AfricaRan2015 to 2017Enrolled175ConditionsInfluenza Viral Infections
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Dayna R ClarkFrom the Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA.
Saad B OmerYale Institute for Global Health.
Milagritos D TapiaCentre pour le Développement des Vaccins, Bamako, Mali.
Marta C NunesMedical Research Council: Respiratory and Meningeal Pathogens Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Clare L CutlandMedical Research Council: Respiratory and Meningeal Pathogens Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
James M TielschDepartment of Global Health, Milken Institute School of Public Health, George Washington University, Washington, Columbia.
Niteen WairagkarBill & Melinda Gates Foundation, Seattle, WA.
Shabir A MadhiMedical Research Council: Respiratory and Meningeal Pathogens Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
for BMGF Supported Maternal Influenza Immunization Trials Investigators Group
University of the Witwatersrand · ZAUniversity of Maryland, Baltimore · USYale University · USEmory University · USGeorge Washington University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

This analysis includes pooled data from 2 placebo-controlled maternal influenza immunization trials, with a separate analysis on a meningococcal conjugate vaccine-controlled maternal influenza immunization trial. Maternal influenza immunization was not associated with infant or maternal all-cause mortality in placebo-controlled trials. In the meningococcal conjugate vaccine-controlled trial, there were fewer deaths during low or any influenza circulation weeks among infants whose mothers received meningococcal conjugate vaccine. ClinicalTrials.gov identifiers: NCT01430689, NCT01034254 and NCT02465190.

Indexed as

Infant MortalityMaternal MortalityAdolescentAdultFemaleHumansIncidenceInfantInfluenza, HumanInfluenza VaccinesMeningococcal InfectionsMeningococcal VaccinesMeta-Analysis as TopicMiddle AgedPregnancyPregnancy Complications, InfectiousInfluenza VaccinesMeningococcal Vaccines

Identifiers

PMID32379201
PMCPMC7279057
OpenAlexW3021059915

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.