ArticleeLife2020
Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
8.3field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 58 citations in OpenAlex.
- Promiscuous RNA binding by WDR5 remodels the KMT2A (MLL1) histone methyltransferase complex to an inactive state.Molecular cell · 2026Article
- From inactivation to intervention: X chromosome silencing in disease pathogenesis and emerging therapeutic strategies.Genes & diseases · 2026Review
- Promiscuous RNA binding by WDR5 remodels the KMT2A (MLL1) histone methyltransferase complex to an inactive state.bioRxiv : the preprint server for biology · 2026Article
- Non-coding RNAs in lipid metabolism and their roles in atherosclerosis.Nature reviews. Cardiology · 2026Review
- Comprehensive CRISPR/Cas9-based mutagenesis identifies single-amino acid substitutions that abrogate SPEN function in X inactivation.Nature communications · 2026Article
- Spen and Nito prevent dedifferentiation of intermediate progenitors by maintaining Notch target expression in stem cells at low levels.Cell reports · 2026Article
- Long noncoding RNA regulation of immunity.Nature immunology · 2026Review
- The Incoming Influenza Genome Assembles a Host RBP Network that Orchestrates Viral RNA Synthesis.bioRxiv : the preprint server for biology · 2025Article
- Article
- Impact of somatic XIST deletions on ongoing XIST expression and inactive X silencing and heterochromatin.Human molecular genetics · 2025Article
- Exome sequencing reveals broad genetic heterogeneity for neuromuscular disorders in consanguineous Pakistani Families.European journal of human genetics : EJHG · 2025Article
- Activation of Pvt1b isoform contributes to local Pvt1 abundance to repress Myc during stress.PLoS genetics · 2025Article
- Human XIST: Origin and Divergence of aNon-coding RNA · 2025Review
- Article
- Transcription regulation by long non-coding RNAs: mechanisms and disease relevance.Nature reviews. Molecular cell biology · 2024Review
- Denaturing purifications demonstrate that PRC2 and other widely reported chromatin proteins do not appear to bind directly to RNA in vivo.Molecular cell · 2024Article
- Unraveling the role of Xist in X chromosome inactivation: insights from rabbit model and deletion analysis of exons and repeat A.Cellular and molecular life sciences : CMLS · 2024Article
- Dissection of protein and RNA regions required for SPEN binding to XIST A-repeat RNA.RNA (New York, N.Y.) · 2024Article
- Regulation of endogenous retroviruses in murine embryonic stem cells and early embryos.Journal of molecular cell biology · 2024Review
- IndiSPENsable for X Chromosome Inactivation and Gene Silencing.Epigenomes · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 5 institutions in 1 country.
Ava C Carter *Center for Personal Dynamic Regulomes, Stanford University, Stanford, United States.ORCID 0000-0002-1892-8742
Jin Xu *Center for Personal Dynamic Regulomes, Stanford University, Stanford, United States.ORCID 0000-0003-0944-9835
Meagan Y Nakamoto *Department of Biochemistry, University of Colorado, Boulder, United States.
Yuning Wei *Center for Personal Dynamic Regulomes, Stanford University, Stanford, United States.
Brian J ZarnegarDepartment of Dermatology, Stanford University School of Medicine, Stanford, United States.
Quanming ShiCenter for Personal Dynamic Regulomes, Stanford University, Stanford, United States.
James P BroughtonCenter for Personal Dynamic Regulomes, Stanford University, Stanford, United States.
Ryan C RansomDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, United States.
Ankit SalhotraDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, United States.
Surya D NagarajaInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, United States.
Rui LiCenter for Personal Dynamic Regulomes, Stanford University, Stanford, United States.
Diana R DouCenter for Personal Dynamic Regulomes, Stanford University, Stanford, United States.ORCID 0000-0001-6269-9636
Kathryn E YostCenter for Personal Dynamic Regulomes, Stanford University, Stanford, United States.
Seung-Woo ChoCenter for Personal Dynamic Regulomes, Stanford University, Stanford, United States.
Anil MistryNovartis Institute for Biomedical Research, Cambridge, United States.
Michael T LongakerDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, United States.
Paul A KhavariDepartment of Dermatology, Stanford University School of Medicine, Stanford, United States.
Robert T BateyDepartment of Biochemistry, University of Colorado, Boulder, United States.
Deborah S WuttkeDepartment of Biochemistry, University of Colorado, Boulder, United States.
Howard Y ChangCenter for Personal Dynamic Regulomes, Stanford University, Stanford, United States.ORCID 0000-0002-9459-4393
Stanford University · USUniversity of Colorado Boulder · USCalifornia Institute for Regenerative Medicine · USHoward Hughes Medical Institute · USNovartis (United States) · US
Funding
Special EquipmentP50HG007735 · NHGRI · STANFORD UNIVERSITY · PI CHANG, HOWARD Y · 2014 to 2018
$15.2MCenter for Personal Dynamic RegulomesRM1HG007735 · NHGRI · STANFORD UNIVERSITY · PI CHANG, HOWARD Y · 2019 to 2023
$13.8MStructural Motifs in RNAR01HG004361 · NHGRI · STANFORD UNIVERSITY · PI CHANG, HOWARD Y · 2007 to 2018
$4.7MPredoctoral Training Molecular BiophysicsT32GM065103 · NIGMS · UNIVERSITY OF COLORADO AT BOULDER · PI FALKE, JOSEPH J · 2002 to 2021
$4.3MStanford Training Program in Aging ResearchT32AG047126 · NIA · STANFORD UNIVERSITY · PI VYJEYANTHI S PERIYAKOIL, TONY WYSS-CORAY · 2014 to 2026
$4.3MRNA Regulation of Transcription Factor ActivityR01GM120347 · NIGMS · UNIVERSITY OF COLORADO · PI WUTTKE, DEBORAH S. · 2016 to 2024
$3.2MCellular and Mechanical Mechanisms Regulating Mandibular Distraction OsteogenesisR01DE026730 · NIDCR · STANFORD UNIVERSITY · PI LONGAKER, MICHAEL T · 2017 to 2021
$1.9MHoward Hughes Medical InstituteNHGRI NIH HHS P50 HG007735NHGRI NIH HHS R01 HG004361NHGRI NIH HHS RM1 HG007735NIA NIH HHS T32 AG047126NIDCR NIH HHS R01 DE026730NIGMS NIH HHS R01 GM120347NIGMS NIH HHS T32 GM065103
Abstract
The
Indexed as
X ChromosomeX Chromosome InactivationAnimalsBinding SitesCell LineDNA-Binding ProteinsDosage Compensation, GeneticEndogenous RetrovirusesFemaleHost-Pathogen InteractionsMiceMouse Embryonic Stem CellsProtein BindingRNA-Binding ProteinsRNA, Long NoncodingRNA, ViralDNA-Binding ProteinsRNA-Binding ProteinsRNA, Long NoncodingRNA, ViralSpen protein, mouseXIST non-coding RNAchromatinchromosomesepigeneticgene expressiongene silencinglong noncoding RNAmousetransposonXist
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.