ArticleeLife2020
Recurrent circuit dynamics underlie persistent activity in the macaque frontoparietal network.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- Neural timescales from a computational perspective.Nature neuroscience · 2026Review
- Selective control of prefrontal neural timescales by parietal cortex.Nature communications · 2026Article
- A Population Coupling Model Identifies Reduced Propagation from V1 to Higher Visual Areas During Locomotion.bioRxiv : the preprint server for biology · 2026Article
- Article
- A common computational and neural anomaly across mouse models of autism.Nature neuroscience · 2025Article
- Increased frontoparietal activity related to lower performance in neuropsychological assessment of working memory.NeuroImage · 2025Article
- Neural basis for individual differences in the attention-enhancing effects of methylphenidate.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The macaque ventral intraparietal functional connectivity patterns reveal an anterio-posterior specialization mirroring that described in human ventral intraparietal area.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Identifying interactions across brain areas while accounting for individual-neuron dynamics with a Transformer-based variational autoencoder.Advances in neural information processing systems · 2025Article
- Cell Type-Specific Profiles and Developmental Trajectories of Transcriptomes in Primate Prefrontal Layer 3 Pyramidal Neurons: Implications for Schizophrenia.The American journal of psychiatry · 2024Article
- Local organization of spatial and shape information in the primate prefrontal cortex.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Signatures of hierarchical temporal processing in the mouse visual system.PLoS computational biology · 2024Article
- Context-invariant beliefs are supported by dynamic reconfiguration of single unit functional connectivity in prefrontal cortex of male macaques.Nature communications · 2024Article
- Common and distinct neural mechanisms of attention.Trends in cognitive sciences · 2024Review
- Representation and computation in visual working memory.Nature human behaviour · 2024Review
- Contributions of narrow- and broad-spiking prefrontal and parietal neurons on working memory tasks.Frontiers in systems neuroscience · 2024Article
- Time-varying generalized linear models: characterizing and decoding neuronal dynamics in higher visual areas.Frontiers in computational neuroscience · 2024Review
- Decoding working memory information from neurons with and without persistent activity in the primate prefrontal cortex.Journal of neurophysiology · 2023Article
- Laminar pattern of adolescent development changes in working memory neuronal activity.Journal of neurophysiology · 2023Article
- Identification of interacting neural populations: methods and statistical considerations.Journal of neurophysiology · 2023Review
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Authors and funding
2 authors.
Funding
Abstract
During delayed oculomotor response tasks, neurons in the lateral intraparietal area (LIP) and the frontal eye fields (FEF) exhibit persistent activity that reflects the active maintenance of behaviorally relevant information. Despite many computational models of the mechanisms of persistent activity, there is a lack of circuit-level data from the primate to inform the theories. To fill this gap, we simultaneously recorded ensembles of neurons in both LIP and FEF while macaques performed a memory-guided saccade task. A population encoding model revealed strong and symmetric long-timescale recurrent excitation between LIP and FEF. Unexpectedly, LIP exhibited stronger local functional connectivity than FEF, and many neurons in LIP had longer network and intrinsic timescales. The differences in connectivity could be explained by the strength of recurrent dynamics in attractor networks. These findings reveal reciprocal multi-area circuit dynamics in the frontoparietal network during persistent activity and lay the groundwork for quantitative comparisons to theoretical models.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.