Evidence map›Paper›PMID 32379042›Full record

Observational studyeLife2020

Quantifying antibiotic impact on within-patient dynamics of extended-spectrum beta-lactamase resistance.

Rene Niehus, Esther van Kleef, Yin Mo, Agata Turlej-Rogacka, Christine Lammens, Yehuda Carmeli, Herman Goossens, Evelina Tacconelli, Biljana Carevic, Liliana Preotescu and 2 more

Open access · goldAbstract readComparative StudyMulticenter StudyObservational Study
In one paragraph

Observational study in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
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  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
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  11. MiniBioReactor Array (MBRA)JAC-antimicrobial resistance · 2022
    Article
  12. Article
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  15. Article
  16. Estimating epidemiologic dynamics from cross-sectional viral load distributions.medRxiv : the preprint server for health sciences · 2021
    Article
  17. Article
  18. Observational
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 7 countries.

Rene NiehusUniversity of Oxford, Oxford, United Kingdom.ORCID 0000-0002-6751-4124
Esther van KleefNational Institute for Public Health and theEnvironment, Bilthoven, Netherlands.
Yin MoUniversity of Oxford, Oxford, United Kingdom.
Agata Turlej-RogackaUniversity of Antwerp, Antwerp, Belgium.
Christine LammensUniversity of Antwerp, Antwerp, Belgium.
Yehuda CarmeliTel-Aviv University, Tel-Aviv, Israel.
Herman GoossensUniversity of Antwerp, Antwerp, Belgium.
Evelina TacconelliUniversity of Tuebingen, Tuebingen, Germany.
Biljana CarevicClinical Centre of Serbia, Belgrade, Serbia.
Liliana PreotescuMatei Balş National Institute for Infectious Diseases, Bucharest, Romania.
Surbhi Malhotra-KumarUniversity of Antwerp, Antwerp, Belgium.
Ben S CooperUniversity of Oxford, Oxford, United Kingdom.ORCID 0000-0002-9445-7217
University of Antwerp · BEUniversity of Oxford · GBCentar za Promociju Nauke · RSNational Institute for Public Health and the Environment · NLTel Aviv University · ILUniversity of Verona · IT

Funding

Department for International Development MR/K006924/1Medical Research Council MR/K006924/1Wellcome TrustWellcome Trust 106698/Z/14/Z
6 · The paper itself

Abstract

Antibiotic-induced perturbation of the human gut flora is expected to play an important role in mediating the relationship between antibiotic use and the population prevalence of antibiotic resistance in bacteria, but little is known about how antibiotics affect within-host resistance dynamics. Here we develop a data-driven model of the within-host dynamics of extended-spectrum beta-lactamase (ESBL) producing

Indexed as

beta-Lactam ResistanceAdultAgedAged, 80 and overAnal CanalAnti-Bacterial AgentsBacterial LoadBacterial Proteinsbeta-LactamasesEnterobacteriaceaeEuropeFemaleGastrointestinal MicrobiomeHumansMaleMiddle AgedAnti-Bacterial AgentsBacterial Proteinsbeta-Lactamasesantibiotic resistanceepidemiologyextended-spectrum beta-lactamaseglobal healthgut microbiotahumaninfectious diseasemicrobiologyresistance carriagestate-space modelwithin-host dynamics

Identifiers

PMID32379042
PMCPMC7205461
OpenAlexW3022340543

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.