ArticleGut microbes2020
Phosphodiesterase 5 (PDE5) restricts intracellular cGMP accumulation during enterotoxigenic
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Article in Gut microbes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.7field-weighted citation impact, top 12% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- A model for Crohn's disease post-ileal resection fibrosis development using human ileal enteroids and myofibroblasts.Frontiers in physiology · 2026Article
- Advancements in understanding bacterial enteritis pathogenesis through organoids.Molecular biology reports · 2024Review
- Shigella-Controlled Human Infection Models: Current and Future Perspectives.Current topics in microbiology and immunology · 2024Review
- Integrating 4-D light-sheet fluorescence microscopy and genetic zebrafish system to investigate ambient pollutants-mediated toxicity.The Science of the total environment · 2023Review
- The role of the minor colonization factor CS14 in adherence to intestinal cell models by geographically diverse ETEC isolates.mSphere · 2023Article
- A Novel Peptide Prevents Enterotoxin- and Inflammation-Induced Intestinal Fluid Secretion by Stimulating Sodium-Hydrogen Exchanger 3 Activity.Gastroenterology · 2023Article
- Cyclic Nucleotide Phosphodiesterases in Alcohol Use Disorders: Involving Gut Microbiota.The international journal of neuropsychopharmacology · 2023Article
- Intestinal organoids as advanced modeling platforms to study the role of host-microbiome interaction in homeostasis and disease.BMB reports · 2023Review
- The role of CFA/I in adherence and toxin delivery by ETEC expressing multiple colonization factors in the human enteroid model.PLoS neglected tropical diseases · 2022Article
- EnterotoxigenicInfection and immunity · 2022Article
- Melatonin reduces inflammation in intestinal cells, organoids and intestinal explants.Inflammopharmacology · 2021Article
- Elevated Extracellular cGMP Produced after Exposure to Enterotoxigenic Escherichia coli Heat-Stable Toxin Induces Epithelial IL-33 Release and Alters Intestinal Immunity.Infection and immunity · 2021Article
- Research in a time of enteroids and organoids: how the human gut model has transformed the study of enteric bacterial pathogens.Gut microbes · 2020Review
- EnterotoxigenicGut microbesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Jennifer Foulke-AbelDivision of Gastroenterology & Hepatology, Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, MD, USA.ORCID 0000-0003-3882-5625
Huimin YuDivision of Gastroenterology & Hepatology, Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, MD, USA.
Laxmi SunuwarDivision of Gastroenterology & Hepatology, Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, MD, USA.
Ruxian LinDivision of Gastroenterology & Hepatology, Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, MD, USA.
James M FleckensteinDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine , St. Louis, MO, USA.ORCID 0000-0002-1148-697X
James B KaperDepartment of Microbiology & Immunology, University of Maryland School of Medicine , Baltimore, MD, USA.
Mark DonowitzDivision of Gastroenterology & Hepatology, Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, MD, USA.
Johns Hopkins University · USUniversity of Maryland, Baltimore · USWashington University in St. Louis · US
Funding
Project 3 - Human colonoids as a model for the pathobiology of EHECP01AI125181 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI FOULKE-ABEL, JENNIFER, KAPER, JAMES B · 2016 to 2025
$18.6MTranslational Research Enhancement CoreP30DK089502 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI ZACHOS, NICHOLAS CONSTANTINE · 2011 to 2020
$12.0MTranslational Approaches to Develop Drug Therapy for DiarrheaR24DK099803 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI DONOWITZ, MARK · 2014 to 2019
$8.9MNovel Antigen Identification for an Enterotoxigenic E. coli VaccineR01AI089894 · NIAID · WASHINGTON UNIVERSITY · PI Zachary T. Berndsen, James Michael Fleckenstein · 2010 to 2026
$7.4MMeasuring the Temporal-Spatial Responses of Dormancy and Drug Resistance in a Human Breast Cancer Metastatic Niche within a Liver-on-a-Chip Microphysiological PlatformUH3TR000503 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TAYLOR, D. LANSING · 2014 to 2016
$6.2MUsing iPSCs to model patient outcomes in nephrotic syndromeUH3TR000504 · NCATS · UNIVERSITY OF WASHINGTON · PI HIMMELFARB, JONATHAN · 2014 to 2016
$6.1MBASIC SCIENCE RESEARCH IN DIGESTIVE DISEASEST32DK007632 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI DONOWITZ, MARK · 1989 to 2018
$5.4MMechanisms and Correction of Abnormal Bicarbonate Secretion by DRA in DiarrheaR01DK116352 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI TSE, CHUNG-MING · 2019 to 2022
$2.2MMolecular Microbiology of Enterotoxigenic E. coli Pathogen-Host InteractionsR01AI126887 · NIAID · WASHINGTON UNIVERSITY · PI FLECKENSTEIN, JAMES MICHAEL · 2016 to 2020
$1.6MHuman Intestinal Organoids: Pre-Clinical Models of Non-Inflammatory DiarrheaU18TR000552 · NCATS · JOHNS HOPKINS UNIVERSITY · PI DONOWITZ, MARK · 2012 to 2014
$1.2MA Human Enteroid Model of Cholera Toxin PathophysiologyK01DK113043 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI FOULKE-ABEL, JENNIFER · 2018 to 2022
$791kBLRD VA I01 BX004825NCATS NIH HHS U18 TR000552NCATS NIH HHS UH3 TR000503NCATS NIH HHS UH3 TR000504NIAID NIH HHS P01 AI125181NIAID NIH HHS R01 AI089894NIAID NIH HHS R01 AI126887NIDDK NIH HHS K01 DK113043NIDDK NIH HHS P30 DK089502NIDDK NIH HHS R01 DK116352NIDDK NIH HHS R24 DK099803NIDDK NIH HHS T32 DK007632
Abstract
Diarrhea caused by enterotoxigenic
Indexed as
Bacterial ToxinsCaco-2 CellsCell Line, TumorCyclic GMPCyclic Nucleotide Phosphodiesterases, Type 5DiarrheaEnterotoxigenic Escherichia coliEnterotoxinsEpithelial CellsEscherichia coli InfectionsEscherichia coli ProteinsFimbriae ProteinsHumansJejunumMembrane GlycoproteinsPeptide HydrolasesBacterial ToxinsCfaE protein, E coliCyclic GMPCyclic Nucleotide Phosphodiesterases, Type 5EatA protein, E coliEnterotoxinsEscherichia coli ProteinsEtpA protein, E coliFimbriae Proteinsheat-labile enterotoxin, E coliheat stable toxin (E coli)Membrane GlycoproteinsPeptide HydrolasesPropionatesQuinolinesverlukastVirulence Factorscyclic nucleotideE. coli heat-labile enterotoxinE. coli heat-stable enterotoxinenteroid monolayerETEChost–pathogen interactionintestinal organoidMRP5PDE5
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.