ArticleImmunity, inflammation and disease2020
Geographic location determines beta-cell autoimmunity among adult Ghanaians: Findings from the RODAM study.
Article in Immunity, inflammation and disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.
- Aetiological research on the health of migrants living in Germany: a systematic literature review.BMJ open · 2022Pooled it
- Subgroups of adult-onset diabetes: a data-driven cluster analysis in a Ghanaian population.Scientific reports · 2023Article
- Islet autoantibody positivity in an adult population with recently diagnosed diabetes in Uganda.PloS one · 2022Article
- City Environment and Occurrence of Neural Autoantibodies in Psychiatric Patients.Frontiers in psychiatry · 2022Article
- Geographic location determines beta-cell autoimmunity among adult Ghanaians: Findings from the RODAM study.Immunity, inflammation and disease · 2020Article
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11 authors at 9 institutions in 5 countries.
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Abstract
introductionBeta-cell autoantibodies are established markers of autoimmunity, which we compared between Ghanaian adults with or without diabetes, living in rural and urban Ghana and in three European cities.
methodsIn the multicenter cross-sectional Research on Obesity and Diabetes among African Migrants (RODAM) study (N = 5898), we quantified autoantibodies against glutamic acid decarboxylase (GAD65Ab) by radioligand binding assay (RBA) and established cut-offs for positivity by displacement analysis. In a subsample, we performed RBA for zinc transporter-8 autoantibodies (ZnT8Ab). Associations of environmental, sociodemographic, and clinical factors with GAD65Ab were calculated.
resultsIn this study population (age: 46.1 ± 11.9 years; female: 62%; Ghana-rural: 1111; Ghana-urban: 1455; Europe: 3332), 9.2% had diabetes with adult-onset. GAD65Ab concentrations were the highest in Ghana-rural (32.4; 10.8-71.3 U/mL), followed by Ghana-urban (26.0; 12.3-49.1 U/mL) and Europe (11.9; 3.0-22.8 U/mL) with no differences between European cities. These distributions were similar for ZnT8Ab. Current fever, history of fever, and higher concentrations of liver enzymes marginally explained site-specific GAD65Ab concentrations. GAD65Ab positivity was as frequent in diabetes as in nondiabetes (5.4% vs 6.1%; P = .25). This was also true for ZnT8Ab positivity.
conclusionGeographic location determines the occurrence of GAD65Ab and ZnT8Ab more than the diabetes status. Beta-cell autoimmunity may not be feasible to differentiate diabetes subgroups in this population.
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