ReviewCardiology journal2020
COVID-19 - Toward a comprehensive understanding of the disease.
Review in Cardiology journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Long-term impact of SARS-CoV-2 infection on cardiorespiratory fitness: a meta-analysis.Frontiers in public health · 2023Pooled it
- Impact of COVID-19 on in-hospital cardiac arrest outcomes: An updated meta-analysis.Cardiology journalPooled it
- A comparison of Gam-COVID-Vac vaccination and non-vaccination on neurological symptoms and immune response in post-COVID-19 syndrome.Qatar medical journal · 2025Article
- COVID-19 infection following influenza vaccine injection and its complications among nurses working in educational-medical hospitals of Ardabil in 2020.Journal of family medicine and primary care · 2023Article
- COVID-19 infection and vaccination against SARS-CoV-2 in myasthenia gravis.Acta neurologica Belgica · 2023Article
- Effects of Multidisciplinary Rehabilitation Program in Patients with Long COVID-19: Post-COVID-19 Rehabilitation (PCR SIRIO 8) Study.Journal of clinical medicine · 2023Article
- Article
- COVID-19 detection using a model of photoplethysmography (PPG) signals.Medical engineering & physics · 2022Article
- Prevalence of COVID-19-associated symptoms during acute infection in relation to SARS-CoV-2-directed humoral and cellular immune responses in a mild-diseased convalescent cohort.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022Article
- Implications of the Immune Polymorphisms of the Host and the Genetic Variability of SARS-CoV-2 in the Development of COVID-19.Viruses · 2022Review
- Successful Treatment of Persistent SARS-CoV-2 Infection in a B-Cell Depleted Patient with Activated Cytotoxic T and NK Cells: A Case Report.International journal of molecular sciences · 2021Article
- Clinical-Pathological Correlation of the Pathophysiology and Mechanism of Action of COVID-19 - a Primer for Clinicians.Current allergy and asthma reports · 2021Review
- Tools and Techniques for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)/COVID-19 Detection.Clinical microbiology reviews · 2021Review
- How do older age, gender and risk groups affect protective behaviours and mental health in the COVID-19 pandemic?International journal of clinical practice · 2021Article
- Pulmonary stromal expansion and intra-alveolar coagulation are primary causes of COVID-19 death.Heliyon · 2021Article
- Health-related quality of life of hospitalized COVID-19 survivors: An initial exploration in Nanning city, China.Social science & medicine (1982) · 2021Article
- Underlying heart diseases and acute COVID-19 outcomes.Cardiology journal · 2021Article
- Cardiovascular comorbidity and death from COVID-19: Prevalence and differential characteristics.Cardiology journal · 2021Article
- SARS-CoV-2 and Pre-existing Vascular Diseases: Guilt by Association?Clinical Medicine Insights. Cardiology · 2021Review
- SARS-CoV-2 Vaccines Based on the Spike Glycoprotein and Implications of New Viral Variants.Frontiers in immunology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The evidence on the pathophysiology of the novel coronavirus SARS-CoV-2 infection is rapidly growing. Understanding why some patients suffering from COVID-19 are getting so sick, while others are not, has become an informal imperative for researchers and clinicians around the globe. The answer to this question would allow rationalizing the fear surrounding this pandemic. Understanding of the pathophysiology of COVID-19 relies on an understanding of interplaying mechanisms, including SARS-CoV-2 virulence, human immune response, and complex inflammatory reactions with coagulation playing a major role. An interplay with bacterial co-infections, as well as the vascular system and microcirculation affected throughout the body should also be examined. More importantly, a compre-hensive understanding of pathological mechanisms of COVID-19 will increase the efficacy of therapy and decrease mortality. Herewith, presented is the current state of knowledge on COVID-19: beginning from the virus, its transmission, and mechanisms of entry into the human body, through the pathological effects on the cellular level, up to immunological reaction, systemic and organ presentation. Last but not least, currently available and possible future therapeutic and diagnostic options are briefly commented on.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.