Evidence map›Paper›PMID 32378727›Full record

ArticleHistology and histopathology2020

Expression and prognostic significance of YAP, TAZ, TEAD4 and p73 in human laryngeal cancer.

Georgios Tsinias, Sofia Nikou, Nicholas Mastronikolis, Vasiliki Bravou, Helen Papadaki

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In one paragraph

Article in Histology and histopathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Georgios Tsinias *Department of Otolaryngology, Head and Neck Surgery, University General Hospital of Patras, Patras, Greece.
Sofia Nikou *Department of Anatomy, Histology and Embryology, University of Patras School of Medicine, Patras, Greece.
Nicholas Mastronikolis *Department of Otolaryngology, Head and Neck Surgery, University General Hospital of Patras, Patras, Greece.
Vasiliki Bravou *Department of Anatomy, Histology and Embryology, University of Patras School of Medicine, Patras, Greece. vibra@upatras.gr.
Helen Papadaki *Department of Anatomy, Histology and Embryology, University of Patras School of Medicine, Patras, Greece. epetrou@upatras.gr.
University of Patras · GR

Funding

- -
6 · The paper itself

Abstract

objectivesThe Hippo signaling pathway plays a critical role in organ size control and tissue homeostasis and its perturbation is associated with tumorigenesis. YAP (Yes associated protein) and TAZ (transcriptional co-activator with PDZ- binding motif) are the major nuclear effectors of the Hippo pathway interacting with TEADs (TEA domain) and p73 transcriptional factors to regulate gene expression. Altered expression of the above proteins promotes tumor initiation, progression and metastasis in a variety of cancer types. This study addresses their expression and prognostic significance in human laryngeal carcinoma.

methodsProtein expression of YAP, TAZ, TEAD4 and p73 was examined by immunohistochemistry in 121 human laryngeal squamous cell carcinomas. Correlations with clinicopathological data and survival were evaluated.

resultsAll proteins were overexpressed in human laryngeal carcinomas compared to non-neoplastic adjacent epithelium. High expression of YAP, TAZ, TEAD4 and p73 correlated significantly with high grade, advanced stage, supraglottic location of tumor, nodal metastases and recurrence. Furthermore, high expression of all proteins was significantly associated with poor overall and disease- free survival. p73 expression proved to be an independent predictive factor of survival and YAP expression proved to be an independent predictive factor of disease recurrence.

conclusionsDeregulation of the expression of the Hippo pathway proteins is implicated in human laryngeal carcinogenesis and YAP and p73 have prognostic significance in the outcome of the disease.

Indexed as

Gene Expression Regulation, NeoplasticAdaptor Proteins, Signal TransducingAdultAgedAged, 80 and overCarcinogenesisCarcinoma, Squamous CellDNA-Binding ProteinsFemaleHumansIntracellular Signaling Peptides and ProteinsLaryngeal NeoplasmsMaleMiddle AgedMuscle ProteinsPrognosisAdaptor Proteins, Signal TransducingDNA-Binding ProteinsIntracellular Signaling Peptides and ProteinsMuscle ProteinsTEAD4 protein, humanTEA Domain Transcription FactorsTP73 protein, humanTranscriptional Coactivator with PDZ-Binding Motif ProteinsTranscription FactorsTumor Protein p73WWTR1 protein, humanYAP1 protein, humanYAP-Signaling Proteins

Identifiers

PMID32378727
OpenAlexW3022616389

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.