ArticleJournal of atherosclerosis and thrombosis2021
Weight Change and Mortality from Cardiovascular Diseases: The Japan Collaborative Cohort Study.
Article in Journal of atherosclerosis and thrombosis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 11 citations in OpenAlex.
- Associations of Change in Body Size With All-Cause and Cause-Specific Mortality Among Healthy Older Adults.JAMA network open · 2023Trial
- The role of uric acid in mediating weight change patterns and cardiovascular health.Archives of medical science : AMS · 2025Article
- Relationships of Weight Change from 20 Years of Age with the Risks of All-Cause and Cardiovascular Mortality in Patients with Chronic Kidney Disease.Journal of atherosclerosis and thrombosis · 2024Observational
- Two-year changes in body composition and future cardiovascular events: a longitudinal community-based study.Nutrition & metabolism · 2023Article
- Early-Adulthood Weight Change and Later Physical Activity in Relation to Cardiovascular and All-Cause Mortality: NHANES 1999-2014.Nutrients · 2022Article
- Impact of Body Mass Index on Obesity-Related Cancer and Cardiovascular Disease Mortality; The Japan Collaborative Cohort Study.Journal of atherosclerosis and thrombosis · 2022Article
- Weight Change Since Age 20 and the Risk of Cardiovascular Disease Mortality: A Prospective Cohort Study.Journal of atherosclerosis and thrombosis · 2022Article
- The Lifelong Health Support 10: a Japanese prescription for a long and healthy life.Environmental health and preventive medicine · 2022Review
- Impact of weight change since a young age on cardiovascular mortality risk: a pooled analysis of Japanese epidemiological evidence.Environmental health and preventive medicine · 2022Article
- Does Weight Loss Increase the Risk of Death from and Incidence of Cardiovascular Disease even among Individuals with Overweight or Obesity at 20 Years of Age?Journal of atherosclerosis and thrombosis · 2021Article
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe aim of this study was to assess the association between weight change and mortality due to cardiovascular diseases (CVDs) in a Japanese population.
methodsWe used the data of a population-based prospective cohort study that was conducted from 1988 to 1990 in 45 areas throughout Japan. Among a total of 69,681 men and women aged 40-79 with no history of CVD or cancer at baseline, the association between weight change from 20 years of age to baseline and CVD-related mortality was evaluated.
resultsDuring a median follow-up period of 19.1 years, we observed 4,274 deaths from total CVD. After adjusting for age, sex, and other potential confounding factors, compared with participants with a weight change of ＜2.5 kg (stable weight), participants with a greater weight change (either loss or gain) had an increased risk of mortality from total CVD (U-shaped association). The hazard ratios for the total CVD risk in participants with a weight loss and a weight gain of ≥ 12.5 kg were 1.50 (95% confidence interval [CI], 1.30-1.72) and 1.21 (95% CI, 1.07-1.36), respectively. The associations between weight change and risk of mortality from ischemic heart disease or stroke showed similar trends. The risk of intracerebral hemorrhage was associated with weight loss only. Weight change was not associated with mortality from subarachnoid hemorrhage.
conclusionsWeight loss or gain could be a risk factor for mortality from total or ischemic CVD, while weight loss could be a risk factor for intracerebral hemorrhage.
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