ArticlePhysiological reports2020
The effect of age on cerebral blood flow responses during repeated and sustained stand to sit transitions.
Article in Physiological reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Risk of post-revascularization stroke in Moyamoya disease: A systematic review, meta-analysis, and meta-regression.Neurosurgical review · 2026Pooled it
- A systematic review, meta-analysisJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Pooled it
- Amelioration of sleep-disordered breathing with supplemental oxygen in older adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Trial
- Article
- Effects of a high-sugar mixed meal on cerebrovascular haemodynamics in young, healthy versus middle-aged adults with cardiometabolic risk factors.Experimental physiology · 2026Article
- Age alters integrated cerebrovascular and cardiovascular dynamic responses to exercise: insights from a systems modeling approach.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- The effect of slow breathing on cardiovascular and electromyographic responses during standing perturbations in older adults.European journal of ageing · 2025Article
- APOE4 carriers display loss of anticipatory cerebrovascular regulation across the Alzheimer's disease continuum.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Quantification of dynamic cerebral autoregulation: welcome to the jungle!Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Review
- Mechanisms maintaining cerebral perfusion during systemic hypotension are impaired in elderly adults.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- Force sensor reduced measurement error compared with verbal command during sit-to-stand assessment of cerebral autoregulation.Physiological reports · 2023Article
- Transfer function analysis of dynamic cerebral autoregulation: A CARNet white paper 2022 update.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Review
- Cerebrovascular function and its association with systemic artery function and stiffness in older adults with and without mild cognitive impairment.European journal of applied physiology · 2022Article
- Novel application of a force sensor during sit-to-stands to measure dynamic cerebral autoregulation onset.Physiological reports · 2022Article
- Association of Age and Sex With Multi-Modal Cerebral Physiology in Adult Moderate/Severe Traumatic Brain Injury: A Narrative Overview and Future Avenues for Personalized Approaches.Frontiers in pharmacology · 2021Review
- The Utility of Cerebrovascular Reactivity MRI in Brain Rehabilitation: A Mechanistic Perspective.Frontiers in physiology · 2021Review
- The effect of age on cerebral blood flow responses during repeated and sustained stand to sit transitions.Physiological reports · 2020Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAging is associated with impaired cerebrovascular blood flow and function, attributed to reduced vasodilatory capacity of the cerebrovascular network. Older adults may also have an impaired relationship between changes in blood pressure and cerebral blood flow; however, previous reports conflict. This study aimed to compare the blood pressure and cerebral blood flow responses to both repeated and sustained stand-to-sit transitions in young and older adults, and to assess the relationship with cerebrovascular reactivity.
methodsIn 20 young (age: 24 ± 4 years) and 20 older (age: 71 ± 7 years) adults we compared middle cerebral artery flow velocity (MCAv), end-tidal partial pressure of carbon dioxide (P
resultsThe % change in MCAv per % change in MAP (%∆MCAv/%∆MAP) was higher in the older adults than in the young adults during repeated stand-to-sit transitions. During the sustained protocol the %∆MCAv/%∆MAP response was similar in both age groups. A high %∆MCAv/%∆MAP response during the repeated stand-to-sit protocol was associated with low cerebrovascular reactivity to CO
conclusionThese findings suggest that the higher %∆MCAv/%∆MAP during repeated stand-sit transitions was associated with impaired cerebrovascular reactivity. Impairments in endothelial function and vascular stiffness with age may contribute to the altered transient cerebral pressure-flow responses in older adults.
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