Evidence map›Paper›PMID 32378336›Full record

ArticleVeterinary medicine and science2020

Subsynovial connective tissue development in the rabbit carpal tunnel.

Verena J M M Schrier, Alyssa Vrieze, Peter C Amadio

Open access · goldAbstract read
In one paragraph

Article in Veterinary medicine and science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Verena J M M SchrierBiomechanics Laboratory and Tendon and Soft Tissue Biology Laboratory, Mayo Clinic, Rochester, MN, USA.
Alyssa VriezeBiomechanics Laboratory and Tendon and Soft Tissue Biology Laboratory, Mayo Clinic, Rochester, MN, USA.
Peter C AmadioBiomechanics Laboratory and Tendon and Soft Tissue Biology Laboratory, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-2206-4772
Mayo Clinic · US

Funding

Dynamic Ultrasound to Enhance Understanding of Carpal Tunnel SyndromeR01AR062613 · NIAMS · MAYO CLINIC ROCHESTER · PI AMADIO, PETER C. · 2014 to 2018
$1.7M
NIAMS NIH HHS AR062613NIAMS NIH HHS R01 AR062613
6 · The paper itself

Abstract

The carpal tunnel contains the digital flexor tendons and the median nerve, which are embedded in a unique network of fibrovascular interconnected subsynovial connective tissue (SSCT). Fibrous hypertrophy of the SSCT and subsequent adaptations in mechanical response are found in patients with carpal tunnel syndrome (CTS), but not much is known about the development of the SSCT. This observational study describes the morphological development of SSCT using histology and ultramicroscopy in an animal model at four time points between late-term fetuses through adulthood. A transition is seen between 3 days and 6 weeks post-partum from a dense solid SSCT matrix to a complex multilayered structure connected with collagenous fibrils. These preliminary data show a developmental pattern that matches an adaptive response of the SSCT to loading and motion. Understanding the anatomical development aids in recognizing the pathophysiology of CTS and supports research on new therapeutic approaches.

Indexed as

AnimalsCarpal Tunnel SyndromeConnective TissueFemaleForelimbMaleRabbitsAnimal modelCarpal Tunnel SyndromeSubsynovial Connective Tissue

Identifiers

PMID32378336
PMCPMC7738720
OpenAlexW3023557093

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.