ArticleCNS neuroscience & therapeutics2020
Abnormal dynamic functional connectivity in Alzheimer's disease.
Article in CNS neuroscience & therapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed.
- Arousal-driven critical roaming reproduces human functional connectivity dynamics.PLoS biology · 2026Article
- HESREN: A Derivative-Informed Reservoir Framework for Detecting Transient Neural Events and Windowless Estimation of Dynamic Functional Connectivity.Neuroinformatics · 2026Article
- Altered temporal variability-based functional reorganization of brain networks predicts motor outcome after stroke.Journal of neuroengineering and rehabilitation · 2026Article
- Elevation in network dynamics amplifies amyloid-dependent tau pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Dynamics of brain connectivity across the Alzheimer's disease spectrum through magnetoencephalography.Scientific reports · 2026Article
- Altered dynamic functional connectivity characteristics in adolescent depression with childhood trauma: a pilot resting-state EEG study.Frontiers in psychology · 2026Article
- Multimodal non-invasive approaches for early Alzheimer's disease detection: a review of neuroelectrophysiological and neuroimaging techniques.Frontiers in psychiatry · 2026Review
- Blind Identification of Altered Functional Subnetworks in Alzheimer's Disease Using Resting-State fMRI.Biomedical engineering and computational biology · 2026Article
- Spatiotemporal profiling of functional network overlapping modules in Alzheimer's disease.Network neuroscience (Cambridge, Mass.) · 2026Article
- Altered Dynamic Functional Network Connectivity in Post-Stroke Aphasia.Annals of clinical and translational neurology · 2026Article
- Microstates and connectivity states reveal task-related network reorganization in Alzheimer's disease patients.Clinical neurophysiology practice · 2026Article
- Altered dynamic functional connectivity of orbitofrontal cortex underlies olfactory and cognitive impairment in late-life depression.Psychoradiology · 2026Article
- Temporal dynamic changes in functional connectivity of reward network in depressed adolescents and young adults with and without suicidal attempts.BMC psychiatry · 2025Article
- Association between choroid plexus volume and cognitive function in older-age bipolar disorder.BMC psychiatry · 2025Article
- Linking Connectivity Dynamics to Symptom Severity and Cognitive Abilities in Children with Autism Spectrum Disorder: An FNIRS Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A dynamical systems framework for precision psychiatry.NPJ digital medicine · 2025Review
- State-Guided ICA of Functional Network Connectivity Reveals Temporal Signatures of Alzheimer's Disease.medRxiv : the preprint server for health sciences · 2025Article
- Topological and geometric signatures of brain network dynamics in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Dynamic functional connectivity is modulated by the amount of p-Tau231 in blood in cognitively intact participants.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Article
- The negative relationship between brain-age gap and psychological resilience defines the age-related neurocognitive status in older people.GeroScience · 2025Article
11 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors.
Funding
Abstract
aimsAlzheimer's disease (AD) is a progressive neurodegenerative disorder. Previous studies have demonstrated abnormalities in functional connectivity (FC) of AD under the assumption that FC is stationary during scanning. However, studies on the FC dynamics of AD, which may provide more insightful perspectives in understanding the neural mechanisms of AD, remain largely unknown.
methodsCombining the sliding-window approach and the k-means algorithm, we identified three reoccurring dynamic FC states from resting-state fMRI data of 26 AD and 26 healthy controls. The between-group differences both in FC states and in regional temporal variability were calculated, followed by a correlation analysis of these differences with cognitive performances of AD patients.
resultsWe identified three reoccurring FC states and found abnormal FC mainly in the frontal and temporal cortices. The temporal properties of FC states were changed in AD as characterized by decreased dwell time in State I and increased dwell time in State II. Besides, we found decreased regional temporal variability mainly in the somatomotor, temporal and parietal regions. Disrupted dynamic FC was significantly correlated with cognitive performances of AD patients.
conclusionOur findings suggest abnormal dynamic FC in AD patients, which provides novel insights for understanding the pathophysiological mechanisms of AD.
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