Evidence map›Paper›PMID 32378290›Full record

ArticleAngewandte Chemie (International ed. in English)2020

Synthesis and Characterization of Anionic Poly(cyclopentadienylene vinylene) and Its Use in Conductive Hydrogels.

Daniel C Lee, Drew L Sellers, Fan Liu, Andrew J Boydston, Suzie H Pun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Drug delivery to the central nervous system.Nature reviews. Materials · 2022
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Daniel C LeeMolecular Engineering and Sciences Institute, University of Washington, 3946 W Stevens Way NE, Seattle, WA, 98105, USA.
Drew L SellersDepartment of Bioengineering, University of Washington, 3720 15th Avenue NE, Seattle, WA, 98195, USA.
Fan LiuDepartment of Bioengineering, University of Washington, 3720 15th Avenue NE, Seattle, WA, 98195, USA.
Andrew J BoydstonDepartment of Chemistry, Department of Materials Science and Engineering, Department of Chemical and Biological Engineering, University of Wisconsin, Madison, WI, 53706, USA.
Suzie H PunMolecular Engineering and Sciences Institute, University of Washington, 3946 W Stevens Way NE, Seattle, WA, 98105, USA.ORCID 0000-0003-1443-4996

Funding

Ultrasound-aided gene transfer to direct cortical neurogenesis after brain injuryR01NS064404 · NINDS · UNIVERSITY OF WASHINGTON · PI HORNER, PHILIP J, PUN, SUZIE H. · 2009 to 2018
$3.5M
Multimeric Peptide Copolymer Formulations for Targeted Drug Delivery to Treat Nervous System DisordersR01NS118247 · NINDS · UNIVERSITY OF WASHINGTON · PI SELLERS, DREW L · 2020 to 2024
$1.8M
NINDS NIH HHS R01 NS064404NINDS NIH HHS R01 NS118247
6 · The paper itself

Abstract

The use of π-conjugated polymers (CPs) in conductive hydrogels remains challenging due to the water-insoluble nature of most CPs. Conjugated polyelectrolytes (CPEs) are promising alternatives because they have tunable electronic properties and high water-solubility, but they are often difficult to synthesize and thus have not been widely adopted. Herein, we report the synthesis of an anionic poly(cyclopentadienylene vinylene) (aPCPV) from an insulating precursor under mild conditions and in high yield. Functionalized aPCPV is a highly water-soluble CPE that exhibits low cytotoxicity, and we found that doping hydrogels with aPCPV imparts conductivity. We also anticipate that this synthetic strategy, due to its ease and high efficiency, will be widely used to create families of not-yet-explored π-conjugated vinylene polymers.

Indexed as

AnimalsCyclopentanesElectric ConductivityHydrogelsMiceNIH 3T3 CellsOxidation-ReductionPolymersCyclopentanesHydrogelsPolymersconducting polymersconductive hydrogelsconjugated polyelectrolytesring-opening metathesis polymerization

Identifiers

PMID32378290
PMCPMC7485123

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.