Evidence map›Paper›PMID 32378114›Full record

ArticleMycopathologia2020

M2-Polarized Macrophages Determine Human Cutaneous Lesions in Lacaziosis.

Tania Cristina Barboza, Mirian Nacagami Sotto, Luciane Kanashiro-Galo, Arival Cardoso de Brito, Maria Irma Seixas Duarte, Juarez Antonio Simões Quaresma, Carla Pagliari

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mycopathologia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Tania Cristina BarbozaLaboratório da Disciplina de Patologia de Moléstias Transmissíveis, Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, Av Dr Arnaldo, 455, sala 1118, São Paulo, SP, CEP 01246-903, Brazil.
Mirian Nacagami SottoLaboratório da Disciplina de Patologia de Moléstias Transmissíveis, Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, Av Dr Arnaldo, 455, sala 1118, São Paulo, SP, CEP 01246-903, Brazil.ORCID http://orcid.org/0000-0001-6380-7192
Luciane Kanashiro-GaloLaboratório da Disciplina de Patologia de Moléstias Transmissíveis, Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, Av Dr Arnaldo, 455, sala 1118, São Paulo, SP, CEP 01246-903, Brazil.
Arival Cardoso de BritoNúcleo de Medicina Tropical, Universidade Federal do Pará, Belém, PA, Brazil.ORCID http://orcid.org/0000-0002-7133-5321
Maria Irma Seixas DuarteLaboratório da Disciplina de Patologia de Moléstias Transmissíveis, Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, Av Dr Arnaldo, 455, sala 1118, São Paulo, SP, CEP 01246-903, Brazil.
Juarez Antonio Simões QuaresmaNúcleo de Medicina Tropical, Universidade Federal do Pará, Belém, PA, Brazil.ORCID http://orcid.org/0000-0002-6267-9966
Carla PagliariLaboratório da Disciplina de Patologia de Moléstias Transmissíveis, Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, Av Dr Arnaldo, 455, sala 1118, São Paulo, SP, CEP 01246-903, Brazil. cpagliari@usp.br.ORCID http://orcid.org/0000-0001-6210-6917
Universidade de São Paulo · BRUniversidade Federal do Pará · BR

Funding

CNPQ 470512/2013-0
6 · The paper itself

Abstract

Lacaziosis is a cutaneous chronic mycosis caused by Lacazia loboi. Macrophages are important cells in the host immune response in fungal infections. The macrophage population exhibits strong plasticity that varies according to the stimuli in the microenvironment of lesions M1 profile promotes a Th1 pattern of cytokines and a microbicidal function and M2 is related to Th2 cytokines and immunomodulatory response. We investigated the population of M1 and M2 polarized macrophages in human cutaneous lesions. A total of 27 biopsies from human lesions were submitted to an immunohistochemistry protocol using antibodies to detect M1 and M2 macrophages (Arginase-1, CD163, iNOS, RBP-J and cMAF). We could observe high number of cells expressing Arginase1, CD163 and c-MAF that correspond to elements of the M2 profile of macrophage, over iNOS and RBP-J (elements of the M1 profile). The results suggest a predominant phenotype of M2 macrophages, which have an immunomodulatory role and probably contributing to chronicity of Lacaziosis.

Indexed as

Antigens, CDAntigens, Differentiation, MyelomonocyticArginaseBiopsyCD163 AntigenCell PlasticityEpidermisHumansImmunoglobulin J Recombination Signal Sequence-Binding ProteinImmunohistochemistryLacaziaLobomycosisMacrophagesNitric Oxide Synthase Type IIProto-Oncogene Proteins c-mafReceptors, Cell SurfaceAntigens, CDAntigens, Differentiation, MyelomonocyticARG1 protein, humanArginaseCD163 AntigenImmunoglobulin J Recombination Signal Sequence-Binding ProteinMAF protein, humanNitric Oxide Synthase Type IINOS2 protein, humanProto-Oncogene Proteins c-mafRBPJ protein, humanReceptors, Cell SurfaceImmunopathogenesisLacaziosisM1 macrophagesM2 macrophages

Identifiers

PMID32378114
PMCPMC7201388
OpenAlexW3021336715

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.