Evidence map›Paper›PMID 32378036›Full record

ArticleJournal of neurology2020

Overlapping syndrome of MOG-IgG-associated disease and autoimmune GFAP astrocytopathy.

Jiaqi Ding, Kaixi Ren, Jun Wu, Hongzeng Li, Tangna Sun, Yaping Yan, Jun Guo

Abstract readCase Reports
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In one paragraph

Article in Journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jiaqi DingDepartment of Neurology, Tangdu Hospital, Air Force Military Medical University, Xi'an, 710038, China.
Kaixi RenDepartment of Neurology, Tangdu Hospital, Air Force Military Medical University, Xi'an, 710038, China.
Jun WuDepartment of Neurology, Xianyang Central Hospital, Xianyang, 712000, China.
Hongzeng LiDepartment of Neurology, Tangdu Hospital, Air Force Military Medical University, Xi'an, 710038, China.
Tangna SunDepartment of Neurology, Tangdu Hospital, Air Force Military Medical University, Xi'an, 710038, China.
Yaping YanCollege of Life Sciences, Shaanxi Normal University, Xi'an, 710062, China. yaping.yan@snnu.edu.cn.
Jun GuoDepartment of Neurology, Tangdu Hospital, Air Force Military Medical University, Xi'an, 710038, China. guojun_81@163.com.
Shaanxi Normal University · CNXian Yang Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) have been considered to be closely relevant to an inflammatory demyelinating disease of the central nervous system (CNS). Glial fibrillary acidic protein (GFAP) immunoglobulin G (IgG) has been identified as a biomarker for a novel autoimmune astrocytopathy. However, coexistence of MOG-IgG and GFAP-IgG is extremely unusual and only one patient has been described with simultaneous presence of MOG-IgG in serum and GFAP-IgG in cerebrospinal fluid (CSF). Herein, we reported the first case of overlapping syndrome of MOG-IgG-associated disease (MOG-AD) and autoimmune GFAP astrocytopathy in whom MOG-IgG and GFAP-IgG were detected both in serum and CSF. A 20-year-old male patient was referred to our department with the presentation of decreased vision, diplopia and weakness of right limb with unknown reasons. Magnetic resonance imaging (MRI) revealed multiple intracranial lesions presenting hypointensity on T1-weighted images, hyperintensity on T2-weighted and FLAIR images and patchy contrast enhancement. MOG-IgG and GFAP-IgG were detected both in serum and CSF, and the titers of both antibodies fluctuated with the severity of disease. Treatment strategy employing intravenous methylprednisolone pulse therapy followed by oral prednisone with slow tapering resulted in an improvement of his symptoms and a sustained remission. Coexistence of MOG-IgG and GFAP-IgG with distinct underlying pathogeneses necessitates the recommendations to screen all recognized pathogenic antibodies against CNS antigens when an autoimmune disease is suspected, since it shows great significance for definite diagnosis of disease and treatment strategy options.

Indexed as

Autoimmune DiseasesImmunoglobulin GAdultAstrocytesAutoantibodiesGlial Fibrillary Acidic ProteinHumansMaleMyelin-Oligodendrocyte GlycoproteinYoung AdultAutoantibodiesGFAP protein, humanGlial Fibrillary Acidic ProteinImmunoglobulin GMOG protein, humanMyelin-Oligodendrocyte GlycoproteinAutoimmune GFAP astrocytopathyGlial fibrillary acidic proteinMOG-IgG-associated diseaseMyelin oligodendrocyte glycoproteinOverlapping syndrome

Identifiers

PMID32378036
OpenAlexW3023396203

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.