Evidence map›Paper›PMID 32377995›Full record

ArticleClinical rheumatology2020

Role of serum leptin levels and leptin receptor gene polymorphisms in systemic lupus erythematosus.

Abd El-Moaty Ali Afifi, Reham M Shaat, Ola Mohamed Gharbia, M Elhanafy, Al Shimaa Goda Hasan

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Article in Clinical rheumatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

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6citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. An Update on the Role of Leptin in the Immuno-Metabolism of Cartilage.International journal of molecular sciences · 2021
    Review
  6. Article
4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Abd El-Moaty Ali AfifiFaculty of Medicine, Department of Rheumatology and Rehabilitation, Mansoura University, El Gomhoria St., Mansoura, Egypt.
Reham M ShaatFaculty of Medicine, Department of Rheumatology and Rehabilitation, Mansoura University, El Gomhoria St., Mansoura, Egypt. reham1975@yahoo.com.ORCID http://orcid.org/0000-0003-3676-462X
Ola Mohamed GharbiaFaculty of Medicine, Department of Rheumatology and Rehabilitation, Mansoura University, El Gomhoria St., Mansoura, Egypt.
M ElhanafyFaculty of Medicine, Department of Clinical Pathology, Mansoura University, El Gomhoria St., Mansoura, Egypt.
Al Shimaa Goda HasanFaculty of Medicine, Department of Rheumatology and Rehabilitation, Mansoura University, El Gomhoria St., Mansoura, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSerum leptin and leptin receptor gene polymorphisms may play a role in the etiopathogenesis of SLE.

objectiveThis study was undertaken to explore the relationship between serum leptin levels and leptin receptor (LEPR) gene polymorphisms with susceptibility to SLE in Egyptian population and to study their relationships with clinical, laboratory, radiographic findings, and disease activity of SLE (SLEDAI). MATERIALS AND

methodsA total of 50 unrelated female patients, who met the SLICC classification criteria for SLE and fifty healthy blood donors, matched for age, sex, and BMI with SLE patients, serving as a control group, were included in this study. All participants had completed preliminary questionnaires and clinical, laboratory, and radiographic examinations. Serum leptin levels were measured by ELISA assays. LEPR genotyping was done by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method. We compared serum leptin levels and LEPR gene polymorphisms in SLE patients and controls, and we tested their relationships with clinical, laboratory, and radiographic findings and SLEDAI in SLE patients.

resultsThe present study showed significant differences of serum leptin levels between SLE patients and controls (p < 0.001). Moreover, higher frequencies of variant genotype (AA) and (A) allele were found in SLE patients compared to controls (p = 0.008 and 0.001, respectively). No associations were observed between the serum leptin, various LEPR genotypes, and gene alleles and the development of clinical, laboratory, and radiological manifestations. Furthermore, no associations were observed between the various LEPR genotypes or gene alleles and leptin levels (p = 0.633 and 0.337 respectively) in SLE patients. Additionally, no correlations were observed between leptin levels, various genotypes, and alleles with SLEDAI (p = 0.244, 0.741, and 0.838 respectively) in SLE patients.

conclusionSerum leptin and LEPR gene polymorphism increase risk of SLE in Egyptian population; however, they are not associated with the development of clinical, lab, and radiological findings. Disease activity is neither correlated with serum leptin level nor associated with LEPR gene polymorphism. Serum levels of leptin are not associated with LEPR gene polymorphism. Key Points • Serum leptin and LEPR gene polymorphism increase risk of SLE in Egyptian patients. • Serum leptin is not associated with SLE disease activity.

Indexed as

LeptinLupus Erythematosus, SystemicCase-Control StudiesEgyptFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansPolymorphism, GeneticPolymorphism, Single NucleotideReceptors, LeptinLeptinReceptors, LeptinEgyptianLeptinLeptin receptor gene polymorphismSystemic lupus erythematosus

Identifiers

PMID32377995

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.