ArticleJournal of industrial microbiology & biotechnology2020
Identification and characterization of a protein Bro1 essential for sophorolipids synthesis in Starmerella bombicola.
Article in Journal of industrial microbiology & biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Engineering interventions for enhanced sophorolipid biosynthesis: from native producers to recombinant platforms.World journal of microbiology & biotechnology · 2026Review
- Yeast-secreted compounds with antifungal activity-screening, genetic parts, biosynthetic pathways, and regulation.FEMS yeast research · 2025Review
- Production and characterization of novel/chimeric sophorose-rhamnose biosurfactants by introducing heterologous rhamnosyltransferase genes into Starmerella bombicola.Biotechnology for biofuels and bioproducts · 2024Article
- FgUbiH Is Essential for Vegetative Development, Energy Metabolism, and Antioxidant Activity inMicroorganisms · 2024Article
- Functional Characterization of Aldehyde Dehydrogenase inMicroorganisms · 2023Article
- Carbon and nitrogen optimization in solid-state fermentation for sustainable sophorolipid production using industrial waste.Frontiers in bioengineering and biotechnology · 2023Article
- A Cumulative Effect by Multiple-Gene Knockout Strategy Leads to a Significant Increase in the Production of Sophorolipids inFrontiers in bioengineering and biotechnology · 2022Article
- Process Development in Biosurfactant Production.Advances in biochemical engineering/biotechnology · 2022Review
- Identification of Four Secreted Aspartic Protease-Like Proteins Associated With Sophorolipids Synthesis inFrontiers in microbiology · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Sophorolipids (SLs) are surface-active molecules produced by the non-pathogenic yeast Starmerella bombicola CGMCC 1576. Several genes involved in the synthesis of SLs have been identified. However, the regulation mechanism of the synthesis pathway for SLs has not been investigated. We recently discovered a protein in S. bombicola, which is structurally related to Yarrowia lipolytica YlBro1. To identify the function of the protein SbBro1 in S. bombicola, the deletion, overexpression, and complementary mutant strains were constructed. We found that the deletion mutant no longer produced SLs. Transcriptome analysis indicated that the expression levels of the key enzyme genes of SLs biosynthetic pathway were significantly down-regulated in the Δbro1, especially the expression level of cyp52m1 encoding the first rate-limiting enzyme in SL synthesis pathway was down-regulated 13-folds and the expression of fatty acid β-oxidation-related enzymes was also down-regulated. This study can give insight into the regulation of SL synthesis.
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Registered trials
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