Evidence map›Paper›PMID 32377965›Full record

ArticleAging clinical and experimental research2020

The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality.

Petre Cristian Ilie, Simina Stefanescu, Lee Smith

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging clinical and experimental research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04810949 (Effect of Vitamin D Supplementation on the Development of Respiratory Infections), which is not on this map. Cited by 385 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
385citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04810949 naterminatednot on this map

Effect of Vitamin D Supplementation on the Development of Respiratory Infections (COVID-19) in Health Personnel at Hospital Clínica NOVA With Serum Values> 20ng / ml

TypeinterventionalSponsorHospital Clinica NovaRan2020 to 2021Enrolled41ConditionsCovid19, Influenza A, Influenza B, H1N1 InfluenzaArmsVitamine D3 supplementation, Diet and sun exposure
3 · Its place in the literature

Who cites it

385 citing papers in PubMed, 14 syntheses or guidelines pooled it.

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  5. Vitamin D Deficiency and Comorbidities as Risk Factors of COVID-19 Infection: A Systematic Review and Meta-analysis.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2022
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325 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Petre Cristian IlieResearch and Innovation Department, The Queen Elizabeth Hospital Foundation Trust, King's Lynn, UK. dr.cristianilie@gmail.com.
Simina StefanescuThe University of East Anglia, Norfolk, UK.
Lee SmithThe Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

WHO declared SARS-CoV-2 a global pandemic. The present aim was to propose an hypothesis that there is a potential association between mean levels of vitamin D in various countries with cases and mortality caused by COVID-19. The mean levels of vitamin D for 20 European countries and morbidity and mortality caused by COVID-19 were acquired. Negative correlations between mean levels of vitamin D (average 56 mmol/L, STDEV 10.61) in each country and the number of COVID-19 cases/1 M (mean 295.95, STDEV 298.7, and mortality/1 M (mean 5.96, STDEV 15.13) were observed. Vitamin D levels are severely low in the aging population especially in Spain, Italy and Switzerland. This is also the most vulnerable group of the population in relation to COVID-19. It should be advisable to perform dedicated studies about vitamin D levels in COVID-19 patients with different degrees of disease severity.

Indexed as

BetacoronavirusCoronavirus InfectionsCOVID-19HumansItalyPandemicsPneumonia, ViralSARS-CoV-2SpainVitamin DVitamin D DeficiencyVitamin DCalcitriolCholecalciferolCOVID-19SARS-CoV2Vitamin D

Identifiers

PMID32377965
PMCPMC7202265

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.