ReviewJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2020
Cardioinhibitory syncope: from pathophysiology to treatment-should we think on cardioneuroablation?
Review in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Cardioneuroablation: A Comprehensive Review.Reviews in cardiovascular medicine · 2026Review
- Vasovagal syncope and postural orthostatic tachycardia syndrome in adolescents: transcranial doppler versus autonomic function test results.Clinical and experimental pediatrics · 2025Article
- Fluoroscopy-free cardioneuroablation for functional bradycardia: a single-center experience.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025Observational
- Factors affecting the syncopal episodes in pediatric vasovagal syncope.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Evaluation of the clinical value of heart rate variability in predicting vasovagal syncope.Frontiers in cardiovascular medicine · 2025Article
- Cardiac Geometry and Function in Patients with Reflex Syncope.Journal of clinical medicine · 2024Review
- The Brain-Heart Network of Syncope.International journal of molecular sciences · 2024Review
- Relationship between hemodynamic type and syncopal symptoms in pediatric vasovagal syncope.European journal of pediatrics · 2024Article
- Cardioneuroablation Using Epicardial Pulsed Field Ablation for the Treatment of Atrial Fibrillation.Journal of cardiovascular development and disease · 2023Review
- Cardioneuroablation for Treating Vasovagal Syncope: Current Status and Future Directions.Arrhythmia & electrophysiology review · 2023Review
- Sympathetic nerve abnormality in an adolescent patient with cardioinhibitory vasovagal syncope.Journal of cardiology cases · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vasovagal syncope (VVS) is the most common type of syncope; the lone cardioinhibitory syncope represents only a small group of patients; however, the "cardioinhibitory component" is highly prevalent in reflex syncope and can be severe enough to produce asystole, lasting for a few seconds followed by a recovery to sinus beats. The environment in which syncope occurs can compromise life, and in-depth knowledge of the disease can prevent deaths and guide the appropriate management. The therapeutic cornerstone is general measures (increase water and salt) followed by pharmacologic therapy; for cardioinhibitory syncope, both treatments fail most of the time, and the next therapeutic option is pacemaker implantation. However, although the pacemaker causes a reduction in syncope, recurrence is high, and a one-time, effective, and safe intervention would be ideal. Cardioneuroablation (CNA) therapy has been proposed as a pacemaker alternative with these characteristics. CNA has shown a high reduction or even complete syncope elimination during 3 years of follow-up in some studies. Patients also reported prolonged prodromal periods, which allowed them enough time to abort the syncope. Invasive therapies like CNA require further extensive cohort studies, randomized clinical trials, and more substantial follow-up to evaluate adverse side effects. This review highlights syncope pathophysiology, dividing it into a central theory and a peripheral theory, the diagnosis explaining the head-up tilt test protocols, and treatments like CAN, representing it with figures for a simplified understanding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.