ReviewPediatric nephrology (Berlin, Germany)2020
Congenital nephrotic syndrome: is early aggressive treatment needed? Yes.
Review in Pediatric nephrology (Berlin, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- NPHS Mutations in Pediatric Patients with Congenital and Steroid-Resistant Nephrotic Syndrome.International journal of molecular sciences · 2024Pooled it
- Combined impact of rituximab and target care on efficacy, quality of life, adverse reactions and recurrence rate in children with nephrotic syndrome: a randomized controlled trial.BMC pediatrics · 2025Trial
- Genetic insights into congenital and infantile nephrotic syndrome: predicting severity and informing care.Pediatric nephrology (Berlin, Germany) · 2026Review
- Transient Congenital Nephrotic Syndrome in Neonates: Two Case Reports and Review of Recent Literature.Cureus · 2025Article
- Spontaneous bladder perforation with urinary ascites secondary to posterior urethral valves and suspected atypical congenital nephrotic syndrome of a premature neonate: A case report.Urology case reports · 2025Article
- Nutritional management of pediatric nephrotic syndrome regarding oxidative stress and antioxidant balance.Frontiers in immunology · 2025Review
- Heterozygous variants of uncertain significance inAME case reports · 2025Article
- Native nephrectomy in advanced pediatric kidney disease: indications, timing, and surgical approaches.Pediatric nephrology (Berlin, Germany) · 2024Review
- Nephrotic Syndrome: A Review.Cureus · 2024Review
- Neonatal nephrotic syndrome: all is not gloomy.BMJ case reports · 2024Article
- Case report: Unveiling a less severe congenital nephrotic syndrome in a Rapa Nui patient with aFrontiers in nephrology · 2024Article
- Application of the Caprini risk model in preventing deep venous thrombosis formation in patients with nephrotic syndrome.American journal of translational research · 2024Article
- The causal effect of triglyceride and high blood pressure on IgA nephropathy: a Mendelian randomization study.Frontiers in medicine · 2024Article
- Case Report: Novel compound heterozygousFrontiers in pediatrics · 2024Article
- Unilateral nephrectomy for young infants with congenital nephrotic syndrome of the Finnish type.Clinical and experimental nephrology · 2022Article
- Congenital nephrotic syndrome.Journal of perinatology : official journal of the California Perinatal Association · 2021Review
- Risk factors for post-nephrectomy hypotension in pediatric patients.Pediatric nephrology (Berlin, Germany) · 2021Observational
- Use of diuretics in the neonatal period.Pediatric nephrology (Berlin, Germany) · 2021Review
- Renal Involvement in Congenital Cytomegalovirus Infection: A Systematic Review.Microorganisms · 2021Review
- Case Report: CMV-Associated Congenital Nephrotic Syndrome.Frontiers in pediatrics · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Congenital nephrotic syndrome (CNS) was primarily considered one disease entity. Hence, one treatment protocol was proposed in the beginning to all CNS patients. Today, with the help of gene diagnostics, we know that CNS is a heterogeneous group of disorders and therefore, different treatment protocols are needed. The most important gene defects causing CNS are NPHS1, NPHS2, WT1, LAMB2, and PLCE1. Before active treatment, all infants with CNS died. It was stated already in the mid-1980s that intensive medical therapy followed by kidney transplantation (KTx) should be the choice of treatment for infants with severe CNS. In Finland, early aggressive treatment protocol was adopted from the USA and further developed for treatment of children with the Finnish type of CNS. The aim of this review is to state reasons for "early aggressive treatment" including daily albumin infusions, intensified nutrition, and timely bilateral nephrectomy followed by KTx at the age of 1-2 years.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.