Evidence map›Paper›PMID 32377822›Full record

Trial reportGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2020

Tear cytokines as potential biomarkers in non-infectious uveitis: post hoc analysis of a randomised clinical trial.

Ivan V Shirinsky, Anastasia A Biryukova, Natalia Y Kalinovskaya, Valery S Shirinsky

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04183387 (Open-label Randomized Study of Efficacy and Safety of Simvastatin in Uveitis), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04183387 phase2completednot on this map

Open-label Randomized Study of Efficacy and Safety of Simvastatin in Uveitis

TypeinterventionalSponsorFederal State Budgetary Scientific Institution, Research Institute of Fundamental and Clinical ImmunologyRan2014 to 2016Enrolled50ConditionsUveitisArmsSimvastatin 40mg
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Uveitis in Children and Adolescents.Rheumatic diseases clinics of North America · 2021
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ivan V ShirinskyLaboratory of Clinical Immunopharmacology, Federal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology, 6 Zalesskogo str., Novosibirsk, 630099, Russia. ivan.shirinsky@gmail.com.ORCID https://orcid.org/0000-0002-8603-3406
Anastasia A BiryukovaS. N. Fyodorov Eye Microsurgery Complex, Novosibirsk Branch. 10 Kolhidskaya, Novosibirsk, 630071, Russia.
Natalia Y KalinovskayaLaboratory of Clinical Immunopharmacology, Federal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology, 6 Zalesskogo str., Novosibirsk, 630099, Russia.
Valery S ShirinskyLaboratory of Clinical Immunopharmacology, Federal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology, 6 Zalesskogo str., Novosibirsk, 630099, Russia.ORCID https://orcid.org/0000-0002-4922-9303
Research Institute of Fundamental and Clinical Immunology · RUIntersectoral Research and Technology Complex Eye Microsurgery · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe study aimed to evaluate cytokines in tears as potential biomarkers in non-infectious uveitis.

methodsTear samples were obtained using Schirmer strips from 50 patients enrolled in a randomised controlled study of simvastatin in non-infectious uveitis and from a control group of 30 healthy participants. The concentrations of IL-6, IL-8, IL-10, and IFN-γ in tears were measured at the study's baseline and again after 8 weeks of treatment using commercial enzyme-linked immunosorbent assay kits.

resultsThe concentrations of tears IL-6 and IL-10 were increased in patients with non-infectious uveitis in comparison with the healthy participants. Longer disease duration was associated with elevated levels of IL-6. The concentrations of the studied cytokines in tears did not correlate with the extent of eye inflammation at baseline. No link between the changes in cytokine levels and changes in clinical parameters during treatment was observed. Baseline IL-10 concentrations independently predicted the development of the clinical response to treatment at weeks 4 and 8.

conclusionAlthough elevated in non-infectious uveitis patients, tear cytokine levels do not correlate with eye inflammation and are not sensitive to change after treatment. However, the level of IL-10 may be a predictive biomarker of response to the treatment of uveitis.

trial registrationNCT04183387.

Indexed as

AdultBiomarkersCytokinesEnzyme-Linked Immunosorbent AssayFemaleHumansMalePrognosisSeverity of Illness IndexTearsUveitisBiomarkersCytokinesAutoimmuneCytokinesHydroxymethylglutaryl-CoA reductase inhibitorsNon-infectiousStatinsTearsUveitis

Identifiers

PMID32377822
OpenAlexW3022454059

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.