ArticleAnnals of hematology2020
A study of the geographic distribution and associated risk factors of leg ulcers within an international cohort of sickle cell disease patients: the CASiRe group analysis.
Article in Annals of hematology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- The correlation of lupus anticoagulant and anticardiolipin antibodies with hematological parameters and clinical findings in sickle cell disease at steady state phase.Thrombosis journal · 2025Article
- Genotype-dependent albuminuria in adult sickle cell disease in Kinshasa.Annals of hematology · 2025Article
- International variations in body mass index within the CASiRe global cohort of sickle cell disease patients.Journal of sickle cell disease · 2025Article
- Impaired microvascular function in patients with sickle cell anemia and leg ulcers improved with healing.British journal of haematology · 2024Article
- Leg Ulcers in Sickle Cell Disease: A Multifactorial Analysis Highlights the Hemolytic Profile.Hematology reports · 2023Article
- Sickle cell leg ulcer successfully managed by hyperbaric oxygen: a case report.Frontiers in medicine · 2023Article
- Hemoglobin and End-Organ Damage in Individuals with Sickle Cell Disease.Current therapeutic research, clinical and experimental · 2023Article
- Pain Burden in the CASiRe International Cohort of Sickle Cell Patients: United States and Ghana.Pain medicine (Malden, Mass.) · 2022Article
- A Description of the Hemolytic Component in Sickle Leg Ulcer: The Role of Circulating miR-199a-5p, miR-144, and miR-126.Biomolecules · 2022Article
- Clinical and laboratory characterization of adult sickle cell anemia patients in Kinshasa.PloS one · 2022Article
- Prevalence of people with sickle cell disease and leg ulcers in Brazil: Socioeconomic and clinical overview.PloS one · 2022Article
- Global geographic differences in healthcare utilization for sickle cell disease pain crises in the CASiRe cohort.Blood cells, molecules & diseases · 2021Article
- Insights into the skin microbiome of sickle cell disease leg ulcers.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2021Article
- Article
- Enhanced Hypercoagulability in Sickle Cell Anaemia Patients with Chronic Leg Ulcers.Advances in hematology · 2020Article
Corrections and comments
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Authors and funding
23 authors at 14 institutions in 3 countries.
Funding
Abstract
Vasculopathy is a hallmark of sickle cell disease ultimately resulting in chronic end organ damage. Leg ulcer is one of its sequelae, occurring in ~ 5-10% of adult sickle cell patients. The majority of leg ulcer publications to date have emanated from single center cohort studies. As such, there are limited studies on the geographic distribution of leg ulcers and associated risk factors worldwide. The Consortium for the Advancement of Sickle Cell Research (CASiRe) was formed to improve the understanding of the different phenotypes of sickle cell disease patients living in different geographic locations around the world (USA, UK, Italy, Ghana). This cross-sectional cohort sub-study of 659 sickle cell patients aimed to determine the geographic distribution and risk factors associated with leg ulcers. The prevalence of leg ulcers was 10.3% and was associated with older age, SS genotype, male gender, and Ghanaian origin. In fact, the highest prevalence (18.6%) was observed in Ghana. Albuminuria, proteinuria, increased markers of hemolysis (lower hemoglobin, higher total bilirubin), lower oxygen saturation, and lower body mass index were also associated with leg ulceration. Overall, our study identified a predominance of leg ulcers within male hemoglobin SS patients living in sub-Saharan Africa with renal dysfunction and increased hemolysis.
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