Observational studyEuropean radiology2020
Solving the preoperative breast MRI conundrum: design and protocol of the MIPA study.
Observational study in European radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Breast imaging and cancer diagnosis during the COVID-19 pandemic: recommendations from the Italian College of Breast Radiologists by SIRM.La Radiologia medica · 2020Guideline
- Assessing breast MRI image quality: the bMRI-QUAL scoring system.European radiology · 2026Article
- Preoperative breast MRI for invasive ductal carcinoma with or without a DCIS component at needle biopsy: influence on surgical outcomes in the MIPA study.European radiology · 2025Observational
- A beneficial impact of pre-operative MRI in the surgical management of HER2-positive breast cancer.European radiology · 2025Article
- Invasive lobular carcinoma subgroup analysis of the MIPA study: real-world prospective data on preoperative MRI impact across the globe.European radiology · 2025Article
- Preoperative breast MRI reduces reoperations for unilateral invasive lobular carcinoma: a patient-matched analysis from the MIPA study.European radiology · 2025Observational
- Preoperative breast MRI positively impacts surgical outcomes of needle biopsy-diagnosed pure DCIS: a patient-matched analysis from the MIPA study.European radiology · 2024Observational
- Clinical trials for evidence-based radiology: to randomize or not to randomize? This is the question.La Radiologia medica · 2024Article
- Breast Conservation Surgery and Mastectomy Have Similar Locoregional Recurrence After Neoadjuvant Chemotherapy: Results From 1462 Patients on the Prospective, Randomized I-SPY2 Trial.Annals of surgery · 2023Article
- Screening and diagnostic breast MRI: how do they impact surgical treatment? Insights from the MIPA study.European radiology · 2023Observational
- Supine versus Prone 3D Abus Accuracy in Breast Tumor Size Evaluation.Tomography (Ann Arbor, Mich.) · 2022Article
- Magnetic resonance imaging before breast cancer surgery: results of an observational multicenter international prospective analysis (MIPA).European radiology · 2022Observational
- Current and Future Directions of Breast MRI.Journal of clinical medicine · 2021Article
- A Review of Breast Imaging for Timely Diagnosis of Disease.International journal of environmental research and public health · 2021Review
- [Artificial intelligence in breast imaging : Areas of application from a clinical perspective].Der Radiologe · 2021Review
- Preoperative Staging in Breast Cancer: Intraindividual Comparison of Unenhanced MRI Combined With Digital Breast Tomosynthesis and Dynamic Contrast Enhanced-MRI.Frontiers in oncology · 2021Article
- The effect of breast MRI on disease-free and overall survival in breast cancer patients: a retrospective population-based study.Breast cancer research and treatment · 2020Article
Corrections and comments
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Authors and funding
43 authors at 20 institutions in 12 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite its high diagnostic performance, the use of breast MRI in the preoperative setting is controversial. It has the potential for personalized surgical management in breast cancer patients, but two of three randomized controlled trials did not show results in favor of its introduction for assessing the disease extent before surgery. Meta-analyses showed a higher mastectomy rate in women undergoing preoperative MRI compared to those who do not. Nevertheless, preoperative breast MRI is increasingly used and a survey from the American Society of Breast Surgeons showed that 41% of respondents ask for it in daily practice. In this context, a large-scale observational multicenter international prospective analysis (MIPA study) was proposed under the guidance of the European Network for the Assessment of Imaging in Medicine (EuroAIM). The aims were (1) to prospectively and systematically collect data on consecutive women with a newly diagnosed breast cancer, not candidates for neoadjuvant therapy, who are offered or not offered breast MRI before surgery according to local practice; (2) to compare these two groups in terms of surgical and clinical endpoints, adjusting for covariates. The underlying hypotheses are that MRI does not cause additional mastectomies compared to conventional imaging, while reducing the reoperation rate in all or in subgroups of patients. Ninety-six centers applied to a web-based call; 36 were initially selected based on volume and quality standards; 27 were active for enrollment. On November 2018, the target of 7000 enrolled patients was reached. The MIPA study is presently at the analytic phase. Key Points • Breast MRI has a high diagnostic performance but its utility in the preoperative setting is controversial. • A large-scale observational multicenter prospective study was launched to compare women receiving with those not receiving preoperative MRI. • Twenty-seven centers enrolled more than 7000 patients. The study is presently at the analytic phase.
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