Evidence map›Paper›PMID 32377694›Full record

ReviewInternational journal of molecular medicine2020

Towards effective COVID‑19 vaccines: Updates, perspectives and challenges (Review).

Daniela Calina, Anca Oana Docea, Demetrios Petrakis, Alex M Egorov, Aydar A Ishmukhametov, Alexsandr G Gabibov, Michael I Shtilman, Ronald Kostoff, Félix Carvalho, Marco Vinceti and 2 more

Abstract readReview
In one paragraph

Review in International journal of molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 186 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
186citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

186 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Acute disseminated encephalomyelitis (ADEM) following COVID-19 vaccination: A systematic review.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2023
    Pooled it
  3. Pooled it
  4. Impact of COVID-19 on fertility and assisted reproductive technology (ART): a systematic review.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Pooled it
  5. Article
  6. Article
  7. Article
  8. Safety and efficiency of COVID-19 vaccine in North Africa.Human vaccines & immunotherapeutics · 2024
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article

126 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Daniela CalinaDepartment of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Anca Oana DoceaDepartment of Toxicology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Demetrios PetrakisDepartment of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, 71003 Heraklion, Greece.
Alex M EgorovFSBSI 'Chumakov Federal Scientific Center for Research and Development of Immune‑ and Biological Products of Russian Academy of Sciences', 108819 Moscow, Russia.
Aydar A IshmukhametovFSBSI 'Chumakov Federal Scientific Center for Research and Development of Immune‑ and Biological Products of Russian Academy of Sciences', 108819 Moscow, Russia.
Alexsandr G GabibovRussian Academy of Sciences, 119991 Moscow, Russia.
Michael I ShtilmanD.I. Mendeleyev University of Chemical Technology, 125047 Moscow, Russia.
Ronald KostoffSchool of Public Policy, Georgia Institute of Technology, Gainesville, VA 20155, USA.
Félix CarvalhoUCIBIO, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050‑313 Porto, Portugal.
Marco VincetiSection of Public Health, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, I-41125 Modena, Italy.
Demetrios A SpandidosLaboratory of Clinical Virology, Medical School, University of Crete, 71409 Heraklion, Greece.
Aristidis TsatsakisDepartment of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, 71003 Heraklion, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the current context of the pandemic triggered by SARS-COV-2, the immunization of the population through vaccination is recognized as a public health priority. In the case of SARS‑COV‑2, the genetic sequencing was done quickly, in one month. Since then, worldwide research has focused on obtaining a vaccine. This has a major economic impact because new technological platforms and advanced genetic engineering procedures are required to obtain a COVID‑19 vaccine. The most difficult scientific challenge for this future vaccine obtained in the laboratory is the proof of clinical safety and efficacy. The biggest challenge of manufacturing is the construction and validation of production platforms capable of making the vaccine on a large scale.

Indexed as

Viral VaccinesBetacoronavirusCoronavirus InfectionsCOVID-19COVID-19 VaccinesDrug CompoundingDrug DevelopmentHumansPandemicsPatient SafetyPneumonia, ViralSARS-CoV-2Treatment OutcomeVaccinationVaccine PotencyCOVID-19 VaccinesViral Vaccines

Identifiers

PMID32377694
PMCPMC7255458

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.