ArticleMolecular medicine reports2020
Upregulation of microRNA‑1 inhibits proliferation and metastasis of breast cancer.
Article in Molecular medicine reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- The Effect of Physical Activity/Exercise on miRNA Expression and Function in Non-Communicable Diseases-A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Co-expression of bovine leukemia virus and bovine foamy virus-derived miRNAs in naturally infected cattle.Microbiology spectrum · 2025Article
- miRNAs that regulate apoptosis in breast cancer and cervical cancer.Cell biochemistry and biophysics · 2024Review
- Screening and identification of miRNAs negatively regulating FAM83A/Wnt/β-catenin signaling pathway in non-small cell lung cancer.Scientific reports · 2024Article
- Article
- MicroRNA as a promising molecular biomarker in the diagnosis of breast cancer.Frontiers in molecular biosciences · 2024Article
- The important role of miR-1-3p in cancers.Journal of translational medicine · 2023Review
- Article
- Exosomal miRNAs as novel avenues for breast cancer treatment.Frontiers in genetics · 2023Review
- Recent advancements of miRNAs in the treatment of bone diseases and their delivery potential.Current research in pharmacology and drug discovery · 2023Review
- Inhibition of RNA Binding in SND1 Increases the Levels of miR-1-3p and Sensitizes Cancer Cells to Navitoclax.Cancers · 2022Article
- MicroRNA-1: Diverse role of a small player in multiple cancers.Seminars in cell & developmental biology · 2022Review
- Progress on the study of the anticancer effects of artesunate.Oncology letters · 2021Review
- Role of MicroRNAs in Human Osteosarcoma: Future Perspectives.Biomedicines · 2021Review
- Exosomal microRNAs: Pleiotropic Impacts on Breast Cancer Metastasis and Their Clinical Perspectives.Biology · 2021Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have shown that microRNAs (miRs) play a key role in the regulation of cancer development. In the present study, reverse transcription‑quantitative PCR was used to detect the expression of miR‑1 in breast cancer and adjacent tissues, and survival analysis was performed to compare the low‑expression groups with the Kaplan-Meier method. Overexpression of miR‑1 was used to observe the effects on the proliferation, migration and invasion of breast cancer cells in vitro and in vivo. Moreover, Bcl‑2 expression was measured by western blotting and luciferase assays after the overexpression of miR‑1. The present study reported that miR‑1 is expressed at low levels in breast cancer and that cell proliferation, migration and invasion are inhibited in miR‑1‑overexpressing cells. Enhanced miR‑1 expression can also increase cell apoptosis. The present study also demonstrated that Bcl‑2 is a potential target of miR‑1. In vivo studies indicate that overexpression of miR‑1 decreases tumor volume and weight in nude mice. The data from the present study demonstrated for the first time that overexpression of miR‑1 increases the sensitivity of breast cancer cells to paclitaxel and cisplatin. The present study provided new evidence for the important role of miR‑1 in the tumorigenesis and drug sensitivity of breast cancer.
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Registered trials
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