Evidence map›Paper›PMID 32377634›Full record

ArticleNature metabolism2020

Hypothalamic estrogen receptor alpha establishes a sexually dimorphic regulatory node of energy expenditure.

J Edward van Veen, Laura G Kammel, Patricia C Bunda, Michael Shum, Michelle S Reid, Megan G Massa, Douglas Arneson, Jae W Park, Zhi Zhang, Alexia M Joseph and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 97 citations in OpenAlex.

  1. Article
  2. Article
  3. Hypothalamic regulation of energy homeostasis: Quo vadis.Reviews in endocrine & metabolic disorders · 2026
    Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Sex-specific thermoregulatory effects of estrogen signaling inbioRxiv : the preprint server for biology · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Metabolic Messengers: oestradiol.Nature metabolism · 2025
    Review
  17. Article
  18. Article
  19. Article
  20. Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

J Edward van VeenDepartment of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA.
Laura G KammelDepartment of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA.
Patricia C BundaDepartment of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA.
Michael ShumDivision of Endocrinology, Department of Medicine, and Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Michelle S ReidDepartment of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA.
Megan G MassaDepartment of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA.
Douglas ArnesonDepartment of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA.
Jae W ParkDepartment of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA.
Zhi ZhangDepartment of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA.
Alexia M JosephDepartment of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA.
Haley HrncirDepartment of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA.
Marc LiesaDivision of Endocrinology, Department of Medicine, and Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Arthur P ArnoldDepartment of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA.
Xia YangDepartment of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA.
Stephanie M CorreaDepartment of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA.
University of California, Los Angeles · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
Systems Genetics Dissection of Non-alcoholic SteatohepatitisR01DK117850 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Aldons Jake Lusis · 2019 to 2026
$4.6M
DHA Reverses Gene Network Signatures of Fructose-induced Metabolic SyndromeR01DK104363 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YANG, XIA · 2015 to 2019
$2.4M
Genetic Mechanisms in Klinefelter Syndrome-Related BehaviorsR01HD076125 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARNOLD, ARTHUR P, JENTSCH, J. DAVID · 2014 to 2018
$2.3M
Epigenetic regulation of myocardial ischemia/reperfusion injury by X chromosomeR01HL131182 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARNOLD, ARTHUR P, EGHBALI, MANSOUREH · 2016 to 2019
$1.5M
Role of the heme-related mitochondrial antioxidant ABCB10 in alcoholic liver diseaseR01AA026914 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHIRIHAI, ORIAN S · 2019 to 2022
$1.4M
A female-specific neuroendocrine center controlling energy expenditureK01DK098320 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CORREA, STEPHANIE · 2013 to 2015
$370k
Estrogen Receptor Beta-Targeted Treatment to Maintain Cognitive Function During MenopauseF31AG051381 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KAMMEL, LAURA · 2016 to 2017
$71k
NCATS NIH HHS UL1 TR001881NCI NIH HHS P30 CA016042NHLBI NIH HHS R01 HL131182NIAAA NIH HHS R01 AA026914NIA NIH HHS F31 AG051381NICHD NIH HHS R01 HD076125NIDDK NIH HHS K01 DK098320NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK104363NIDDK NIH HHS R01 DK117850
6 · The paper itself

Abstract

Estrogen receptor a (ERa) signaling in the ventromedial hypothalamus (VMH) contributes to energy homeostasis by modulating physical activity and thermogenesis. However, the precise neuronal populations involved remain undefined. Here, we describe six neuronal populations in the mouse VMH by using single-cell RNA transcriptomics and in situ hybridization. ERa is enriched in populations showing sex biased expression of reprimo (

Indexed as

Energy MetabolismSex CharacteristicsAnimalsEstrogen Receptor alphaFemaleFluorescent DyesGenetic MarkersHypothalamusMaleMiceNeuronsEstrogen Receptor alphaFluorescent DyesGenetic Markers

Identifiers

PMID32377634
PMCPMC7202561
OpenAlexW3015968258

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.