Evidence map›Paper›PMID 32377564›Full record

ArticleNPJ breast cancer2020

Evaluation of ductal carcinoma in situ grade via triple-modal molecular imaging of B7-H3 expression.

Sunitha Bachawal, Gregory R Bean, Gregor Krings, Katheryne E Wilson

Open access · goldAbstract read
In one paragraph

Article in NPJ breast cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Molecular Ultrasound Imaging.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
    Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Sunitha Bachawal1Department of Radiology, Molecular Imaging Program at Stanford, Stanford University, School of Medicine, Stanford, CA USA.
Gregory R Bean2Department of Pathology, Stanford University, School of Medicine, Stanford, CA USA.ORCID 0000-0003-2866-8283
Gregor Krings3Department of Pathology, University of California San Francisco, San Francisco, CA USA.
Katheryne E Wilson1Department of Radiology, Molecular Imaging Program at Stanford, Stanford University, School of Medicine, Stanford, CA USA.ORCID 0000-0003-1388-9446
Stanford Medicine · USUniversity of California, San Francisco · US

Funding

VECTOR COREP30NS069375 · NINDS · STANFORD UNIVERSITY · PI STEINBERG, GARY K · 2011 to 2019
$6.3M
Molecular Ultrasound for Early Breast Cancer DetectionR01CA155289 · NCI · STANFORD UNIVERSITY · PI WILLMANN, JUERGEN KARL · 2011 to 2015
$1.6M
Molecular Spectroscopic Photoacoustic Imaging for Breast Lesion CharacterizationR21EB022214 · NIBIB · STANFORD UNIVERSITY · PI WILSON, KATHERYNE E · 2016 to 2017
$439k
Spectroscopic Photoacoustic Molecular Imaging for Breast Lesion CharacterizationK99EB023279 · NIBIB · STANFORD UNIVERSITY · PI WILSON, KATHERYNE E · 2017 to 2018
$152k
NCI NIH HHS R01 CA155289NIBIB NIH HHS K99 EB023279NIBIB NIH HHS R21 EB022214NINDS NIH HHS P30 NS069375
6 · The paper itself

Abstract

Ductal carcinoma in situ (DCIS) will account for 62,930 cases of breast cancer in 2019. DCIS is a pre-invasive lesion which may not progress to invasive carcinoma, yet surgery remains the mainstay treatment. Molecular imaging of a specific marker for DCIS grade for detection and active surveillance are critically needed to reduce potential overtreatment. First, breast cancer marker B7-H3 (CD276) expression was evaluated by immunohistochemical staining in 123 human specimens including benign epithelium (H-score 10.0 ± 8.2) and low (20.8 ± 17.7), intermediate (87.1 ± 69.5), and high (159.1 ± 87.6) grade DCIS, showing a positive association with DCIS nuclear grade (

Indexed as

Breast cancerCancer imagingTumour biomarkers

Identifiers

PMID32377564
PMCPMC7190737
OpenAlexW3022510712

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.