Evidence map›Paper›PMID 32377530›Full record

ArticleJournal of immunology research2020

A Multiple Antigen Peptide Vaccine Containing CD4

Yuan Gu, Ximeng Sun, Jingjing Huang, Bin Zhan, Xinping Zhu

Open access · goldAbstract read
In one paragraph

Article in Journal of immunology research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Bioinformatics and biology insights · 2026
    Article
  4. Frontiers in immunology · 2026
    Article
  5. Design of a Multi-Epitope Vaccine Based onInternational journal of molecular sciences · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. A NovelInternational journal of molecular sciences · 2024
    Article
  10. Article
  11. Vaccines as a Strategy to Control Trichinellosis.Frontiers in microbiology · 2022
    Review
  12. Article
  13. A comprehensive and critical overview of schistosomiasis vaccine candidates.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2021
    Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Yuan GuDepartment of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.ORCID https://orcid.org/0000-0001-5480-5937
Ximeng SunDepartment of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.ORCID https://orcid.org/0000-0002-6469-3518
Jingjing HuangDepartment of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.ORCID https://orcid.org/0000-0001-8071-1715
Bin ZhanDepartment of Pediatrics, Section of Tropical Medicine, Baylor College of Medicine, Houston, Texas 77030, USA.ORCID https://orcid.org/0000-0002-6884-9452
Xinping ZhuDepartment of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.ORCID https://orcid.org/0000-0003-0460-3514
Capital Medical University · CNBaylor College of Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiepitope peptide vaccine has some advantages over traditional recombinant protein vaccine due to its easy and fast production and possible inclusion of multiple protective epitopes of pathogens. However, it is usually poorly immunogenic and needs to conjugate to a large carrier protein. Peptides conjugated to a central lysine core to form multiple antigen peptides (MAPs) will increase the immunogenicity of peptide vaccine. In this study, we constructed a MAP consisting of CD4

Indexed as

AnimalsAntibodies, HelminthAntigens, HelminthB-LymphocytesCD4-Positive T-LymphocytesEpitopes, B-LymphocyteEpitopes, T-LymphocyteFemaleGerminal CenterHumansImmunity, HumoralMiceMice, Inbred BALB CPeptidesT-Lymphocyte SubsetsTrichinella spiralisAntibodies, HelminthAntigens, HelminthEpitopes, B-LymphocyteEpitopes, T-LymphocytePeptidesTropomyosinVaccines, Subunit

Identifiers

PMID32377530
PMCPMC7199560
OpenAlexW2999287241

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.