Evidence map›Paper›PMID 32377295›Full record

ArticleOxidative medicine and cellular longevity2020

New Synthetic 3-Benzoyl-5-Hydroxy-2

Chiung-Mei Chen, Wan-Ling Chen, Shu-Ting Yang, Te-Hsien Lin, Shu-Mei Yang, Wenwei Lin, Chih-Ying Chao, Yih-Ru Wu, Kuo-Hsuan Chang, Guey-Jen Lee-Chen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. The Role of NRF2 in Trinucleotide Repeat Expansion Disorders.Antioxidants (Basel, Switzerland) · 2024
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Chiung-Mei ChenDepartment of Neurology, Chang-Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan 33302, Taiwan.ORCID https://orcid.org/0000-0002-0769-0353
Wan-Ling ChenDepartment of Neurology, Chang-Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan 33302, Taiwan.
Shu-Ting YangDepartment of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan.
Te-Hsien LinDepartment of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan.ORCID https://orcid.org/0000-0002-1107-772X
Shu-Mei YangDepartment of Chemistry, National Taiwan Normal University, Taipei 11677, Taiwan.
Wenwei LinDepartment of Chemistry, National Taiwan Normal University, Taipei 11677, Taiwan.
Chih-Ying ChaoDepartment of Neurology, Chang-Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan 33302, Taiwan.
Yih-Ru WuDepartment of Neurology, Chang-Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan 33302, Taiwan.ORCID https://orcid.org/0000-0003-1191-2542
Kuo-Hsuan ChangDepartment of Neurology, Chang-Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan 33302, Taiwan.ORCID https://orcid.org/0000-0003-4972-9823
Guey-Jen Lee-ChenDepartment of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan.ORCID https://orcid.org/0000-0003-4818-9917
Chang Gung University · TWNational Taiwan Normal University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinocerebellar ataxia type 17 (SCA17) is caused by a CAG/CAA expansion mutation encoding an expanded polyglutamine (polyQ) tract in TATA-box binding protein (TBP), a general transcription initiation factor. Suppression of cAMP-responsive element binding protein- (CREB-) dependent transcription, impaired nuclear factor erythroid 2-related factor 2 (NRF2) signaling, and interaction of AMP-activated protein kinase (AMPK) with increased oxidative stress have been implicated to be involved in pathogenic mechanisms of polyQ-mediated diseases. In this study, we demonstrated decreased pCREB and NRF2 and activated AMPK contributing to neurotoxicity in SCA17 SH-SY5Y cells. We also showed that licochalcone A and the related in-house derivative compound 3-benzoyl-5-hydroxy-2

Indexed as

Aminoimidazole CarboxamideAMP-Activated Protein KinasesChalconesChromonesCyclic AMP Response Element-Binding ProteinHumansNeuronal OutgrowthNF-E2-Related Factor 2PeptidesRibonucleotidesSpinocerebellar AtaxiasTATA-Box Binding ProteinAICA ribonucleotideAminoimidazole CarboxamideAMP-Activated Protein KinasesChalconesChromonesCREB1 protein, humanCyclic AMP Response Element-Binding Proteinlicochalcone ANFE2L2 protein, humanNF-E2-Related Factor 2PeptidespolyglutamineRibonucleotidesTATA-Box Binding ProteinTBP protein, human

Identifiers

PMID32377295
PMCPMC7195640
OpenAlexW3019571910

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.