Evidence map›Paper›PMID 32377294›Full record

ArticleOxidative medicine and cellular longevity2020

Fernblock® Upregulates NRF2 Antioxidant Pathway and Protects Keratinocytes from PM

Pablo Delgado-Wicke, Azahara Rodríguez-Luna, Yoshifumi Ikeyama, Yoichi Honma, Toshiaki Kume, María Gutierrez, Silvia Lorrio, Ángeles Juarranz, Salvador González

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Potential Value of a Combination ofPharmaceuticals (Basel, Switzerland) · 2026
    Article
  2. Changes in ultraviolet B radiation-induced DNA damage and erythema after oral nicotinamide and polypodium leucotomos in healthy volunteers: an intraindividual controlled trial.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025
    Article
  3. Exploring the In Vitro Photoprotective Effect of a Combination ofInternational journal of molecular sciences · 2025
    Article
  4. Clinical Applications ofLife (Basel, Switzerland) · 2023
    Review
  5. Uses ofJournal of clinical medicine · 2023
    Article
  6. Protective Effect of the Hydrophilic Extract ofAntioxidants (Basel, Switzerland) · 2022
    Article
  7. Article
  8. Sunscreens and Photoaging: A Review of Current Literature.American journal of clinical dermatology · 2021
    Review
  9. The potential effect of Polypodium leucotomos extract on ultraviolet- and visible light-induced photoaging.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2021
    Review
  10. The Aqueous Extract ofAntioxidants (Basel, Switzerland) · 2021
    Article
  11. Therapeutic Potential ofFrontiers in pharmacology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Pablo Delgado-Wicke *Department of Biology, Faculty of Sciences, Autónoma University of Madrid (UAM) 28049, Madrid, Spain.ORCID https://orcid.org/0000-0003-3988-3704
Azahara Rodríguez-Luna *Medical Affairs Department, Cantabria Labs, 28043 Madrid, Spain.ORCID https://orcid.org/0000-0002-1529-7674
Yoshifumi IkeyamaRohto Basic Research Development Division, Tokyo, Japan.ORCID https://orcid.org/0000-0002-0662-491X
Yoichi HonmaRohto Basic Research Development Division, Tokyo, Japan.
Toshiaki KumeDepartment of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama, Japan.
María GutierrezDepartment of Biology, Faculty of Sciences, Autónoma University of Madrid (UAM) 28049, Madrid, Spain.ORCID https://orcid.org/0000-0001-5868-8790
Silvia LorrioDepartment of Biology, Faculty of Sciences, Autónoma University of Madrid (UAM) 28049, Madrid, Spain.
Ángeles JuarranzDepartment of Biology, Faculty of Sciences, Autónoma University of Madrid (UAM) 28049, Madrid, Spain.ORCID https://orcid.org/0000-0002-6574-2887
Salvador GonzálezInstituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain.ORCID https://orcid.org/0000-0001-9282-4784
Universidad Autónoma de Madrid · ESRohto Pharmaceutical (Japan) · JPInstituto Ramón y Cajal de Investigación Sanitaria · ESUniversidad de Alcalá · ESUniversidad de Cantabria · ESUniversity of Toyama · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Humans in modern industrial and postindustrial societies face sustained challenges from environmental pollutants, which can trigger tissue damage from xenotoxic stress through different mechanisms. Thus, the identification and characterization of compounds capable of conferring antioxidant effects and protection against these xenotoxins are warranted. Here, we report that the natural extract of

Indexed as

AntioxidantsHumansKeratinocytesNF-E2-Related Factor 2Plant ExtractsProtective AgentsUp-RegulationAntioxidantsfernblockNF-E2-Related Factor 2Plant ExtractsProtective Agents

Identifiers

PMID32377294
PMCPMC7181013
OpenAlexW3016892230

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.