Evidence map›Paper›PMID 32376999›Full record

ArticleMolecular psychiatry2021

Thalamic and prefrontal GABA concentrations but not GABA

Lawrence K Fung, Ryan E Flores, Meng Gu, Kevin L Sun, David James, Rachel K Schuck, Booil Jo, Jun Hyung Park, Byung Chul Lee, Jae Ho Jung and 8 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Diverse excess GABA modes drive autism and epilepsy-autism comorbidity.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Article
  7. GABAFrontiers in pharmacology · 2026
    Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. In vivo translocator protein in females with autism spectrum disorder: a pilot study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Resting-State Functional MRI and PET Imaging as Noninvasive Tools to Study (Ab)Normal Neurodevelopment in Humans and Rodents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 2 countries.

Lawrence K FungDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, 94305, USA. lkfung@stanford.edu.ORCID http://orcid.org/0000-0002-5738-0396
Ryan E FloresDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, 94305, USA.
Meng GuDepartment of Radiology, Stanford University, Stanford, CA, 94305, USA.
Kevin L SunDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, 94305, USA.
David JamesDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, 94305, USA.
Rachel K SchuckDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, 94305, USA.
Booil JoDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, 94305, USA.
Jun Hyung ParkDepartment of Radiology, Stanford University, Stanford, CA, 94305, USA.
Byung Chul LeeDepartment of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Seoul, South Korea.
Jae Ho JungBio Imaging Korea Seoul, Co., Ltd., Seoul, South Korea.
Sang Eun KimDepartment of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Seoul, South Korea.
Manish SaggarDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, 94305, USA.
Matthew D SacchetDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, 94305, USA.
Geoff WarnockPMOD Technologies Ltd, Zürich, Switzerland.
Mohammad Mehdi KhalighiDepartment of Radiology, Stanford University, Stanford, CA, 94305, USA.
Daniel SpielmanDepartment of Radiology, Stanford University, Stanford, CA, 94305, USA.
Frederick T ChinDepartment of Radiology, Stanford University, Stanford, CA, 94305, USA.
Antonio Y HardanDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, 94305, USA.
Stanford University · USSeoul National University Bundang Hospital · KRBio-Medical Science (South Korea) · KR

Funding

Cross-Species Multi-Modal Neuroimaging to Investigate GABA Physiology in Fragile X SyndromeR01HD084214 · NICHD · STANFORD UNIVERSITY · PI CHIN, FREDERICK T · 2014 to 2018
$2.7M
Robust 1H MRSI of GABA, Glutamate, Glutamine, and Glutathione R01MH110683 · NIMH · STANFORD UNIVERSITY · PI SPIELMAN, DANIEL M · 2017 to 2020
$1.5M
GABAergic Neurophysiology in Autism Spectrum DisorderK08MH111750 · NIMH · STANFORD UNIVERSITY · PI FUNG, LAWRENCE · 2016 to 2019
$780k
NICHD NIH HHS R01 HD084214NIMH NIH HHS K08 MH111750NIMH NIH HHS R01 MH110683
6 · The paper itself

Abstract

The gamma aminobutyric acid (GABA) neurotransmission system has been implicated in autism spectrum disorder (ASD). Molecular neuroimaging studies incorporating simultaneous acquisitions of GABA concentrations and GABA

Indexed as

Autism Spectrum DisorderAutistic DisorderAdultFemalegamma-Aminobutyric AcidHumansMalePrefrontal CortexThalamusgamma-Aminobutyric Acid

Identifiers

PMID32376999
PMCPMC7644591
OpenAlexW3023876246

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.