ArticleScientific reports2020
Intraoperative Laser Speckle Contrast Imaging For Real-Time Visualization of Cerebral Blood Flow in Cerebrovascular Surgery: Results From Pre-Clinical Studies.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 52 citations in OpenAlex.
- In Vivo Monitoring of Pressure Ulcer Model Development and Recoverability Under Multimodal Parameters Within a Unified Field of View.Journal of biophotonics · 2026Article
- Neurovascular coupling and cerebrovascular reactivity: physiology, lifespan development, pathophysiology, and clinical relevance.Frontiers in physiology · 2026Review
- Advanced Image-Guidance and Surgical-Navigation Techniques for Real-Time Visualized Surgery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Advancing intraoperative cerebral blood flow monitoring: integrating imaging photoplethysmography and laser speckle contrast imaging in neurosurgery.Frontiers of optoelectronics · 2025Article
- Mapping of blood flow and slow speckle tissue dynamics using laser speckle contrast imaging.Biomedical optics express · 2025Article
- Studies ofJournal of biomedical optics · 2025Article
- Intraoperative neuromonitoring as an independent predictor for postoperative delirium in ICU following aneurysm clipping.eNeurologicalSci · 2025Article
- Article
- Quantum machine learning enhanced laser speckle analysis for precise speed prediction.Scientific reports · 2024Article
- Impact of light polarization on laser speckle contrast imaging with a custom phantom for microvascular flow.Scientific reports · 2024Article
- Dual-mode optical projection mapping system: integration of laser speckle contrast and subcutaneous vein imaging.Biomedical engineering letters · 2024Article
- Advancing DIEP Flap Monitoring with Optical Imaging Techniques: A Narrative Review.Sensors (Basel, Switzerland) · 2024Review
- High spatiotemporal mapping of cortical blood flow velocity with an enhanced accuracy.Biomedical optics express · 2024Article
- Realtime assessment of vascular occlusion and reperfusion in animal models of intraoperative imaging - a pilot study.Innovative surgical sciences · 2024Article
- Microcirculatory changes in the skin after postmastectomy radiotherapy in women with breast cancer.Scientific reports · 2024Article
- Real-time laser speckle contrast imaging for intraoperative neurovascular blood flow assessment: animal experimental study.Scientific reports · 2024Article
- SpeckleCam: high-resolution computational speckle contrast tomography for deep blood flow imaging.Biomedical optics express · 2023Article
- Projection mapping system for laser speckle contrast image: feasibility study for clinical application.Journal of biomedical optics · 2023Article
- Single Quasi-Symmetrical LED with High Intensity and Wide Beam Width Using Diamond-Shaped Mirror Refraction Method for Surgical Fluorescence Microscope Applications.Diagnostics (Basel, Switzerland) · 2023Article
- Comparison of ketamine/xylazine and isoflurane anesthesia on the establishment of mouse middle cerebral artery occlusion model.Experimental animals · 2023Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Cerebrovascular surgery can benefit from an intraoperative system that conducts continuous monitoring of cerebral blood flow (CBF). Such a system must be handy, non-invasive, and directly integrated into the surgical workflow. None of the currently available techniques, considered alone, meets all these criteria. Here, we introduce the SurgeON™ system: a newly developed non-invasive modular tool which transmits high-resolution Laser Speckle Contrast Imaging (LSCI) directly onto the eyepiece of the surgical microscope. In preclinical rodent and rabbit models, we show that this system enabled the detection of acute perfusion changes as well as the recording of temporal response patterns and degrees of flow changes in various microvascular settings, such as middle cerebral artery occlusion, femoral artery clipping, and complete or incomplete cortical vessel cautery. During these procedures, a real-time visualization of vasculature and CBF was available in high spatial resolution through the eyepiece as a direct overlay on the live morphological view of the surgical field. Upon comparison with indocyanine green angiography videoangiography (ICG-VA) imaging, also operable via SurgeON, we found that direct-LSCI can produce greater information than ICG-VA and that continuous display of data is advantageous for performing immediate LSCI-guided adjustments in real time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.