Evidence map›Paper›PMID 32376954›Full record

ArticleNature2020

APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline.

Axel Montagne, Daniel A Nation, Abhay P Sagare, Giuseppe Barisano, Melanie D Sweeney, Ararat Chakhoyan, Maricarmen Pachicano, Elizabeth Joe, Amy R Nelson, Lina M D'Orazio and 17 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07655687 (Intraoperative Targeted Temperature Management on Delayed Neurocognitive Recovery in Older Patients After Major Cancer Surgery), which is not on this map. Cited by 809 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
809citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07655687 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Intraoperative Targeted Temperature Management on Delayed Neurocognitive Recovery in Older Patients After Major Cancer Surgery: a Multicenter Randomized Trial

TypeinterventionalSponsorPeking University First HospitalRan2026 to 2028Enrolled1,512ConditionsElderly Patients, Cancer Surgery, Hypothermia, Accidental, Targeted Temperature ManagementArmsTarget temperature management, Routine thermal management
3 · Its place in the literature

Who cites it

809 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Incidence, severity, and associated risk factors for amyloid-related imaging abnormalities in anti-amyloid monoclonal antibody therapy for early Alzheimer's disease: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Pooled it
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  7. International journal of molecular sciences · 2025
    Pooled it
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  11. A phase 2A/B randomized trial of metabolic modulators intranasal insulin and empagliflozin for MCI and early AD.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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  20. Brain, behavior, & immunity - health · 2026
    Article

749 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors.

Axel Montagne *Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-5564-985X
Daniel A Nation *Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Abhay P Sagare *Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Giuseppe Barisano *Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-5598-1369
Melanie D Sweeney *Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Ararat ChakhoyanDepartment of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Maricarmen PachicanoDepartment of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Elizabeth JoeAlzheimer's Disease Research Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Amy R NelsonDepartment of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Lina M D'OrazioAlzheimer's Disease Research Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
David P BuennagelHuntington Medical Research Institutes, Pasadena, CA, USA.
Michael G HarringtonHuntington Medical Research Institutes, Pasadena, CA, USA.
Tammie L S BenzingerDepartment of Radiology, Washington University School of Medicine, St Louis, MO, USA.
Anne M FaganThe Hope Center for Neurodegenerative Disorders, Washington University School of Medicine, St Louis, MO, USA.
John M RingmanAlzheimer's Disease Research Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Lon S SchneiderAlzheimer's Disease Research Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
John C MorrisDepartment of Neurology, Washington University School of Medicine, St Louis, MO, USA.
Eric M ReimanBanner Alzheimer Institute, Phoenix, AZ, USA.ORCID http://orcid.org/0000-0002-0705-3696
Richard J CaselliDepartment of Neurology, Mayo Clinic, Scottsdale, AZ, USA.
Helena C ChuiAlzheimer's Disease Research Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Julia TcwDepartment of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-3054-9374
Yining ChenDepartment of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Judy PaAlzheimer's Disease Research Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Peter S ContiMolecular Imaging Center, Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Meng LawAlzheimer's Disease Research Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Arthur W TogaAlzheimer's Disease Research Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Berislav V ZlokovicDepartment of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. zlokovic@usc.edu.ORCID http://orcid.org/0000-0002-6802-8232

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI CHENGJIE XIONG · 1985 to 2026
$69.5M
WASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 1985 to 2019
$52.1M
The natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI SCHINDLER, SUZANNE ELIZABETH · 2005 to 2025
$49.5M
VASCULAR RISK AND COGNITIVE STATUS IN A LATINO POPULATIONP50AG005142 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ARANDA, MARIA P. · 1985 to 2019
$41.0M
UC Irvine Alzheimer's Disease Research Center Induced Pluripotent Stem Cell CoreP50AG016573 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI LAFERLA, FRANK M · 2000 to 2019
$37.0M
Research Education ComponentP30AG019610 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI GONZALEZ HERNANDEZ, GRACIELA · 2001 to 2020
$32.5M
Research Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI DAVID M. HOLTZMAN · 2020 to 2026
$28.7M
Vascular Contributions to Dementia and Genetic Risk Factors for Alzheimer's DiseaseP01AG052350 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Daniel A Nation, ARTHUR W TOGA · 2016 to 2026
$28.4M
USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI, ARTHUR W TOGA · 2020 to 2026
$27.8M
PET, APOE & the Preclinical Course of Alzheimer's DiseaseR01AG031581 · NIA · BANNER ALZHEIMER'S INSTITUTE · PI CASELLI, RICHARD J., REIMAN, ERIC MICHAEL · 2008 to 2018
$16.6M
THE XNAT IMAGING INFORMATICS PLATFORMR01EB009352 · NIBIB · WASHINGTON UNIVERSITY · PI Daniel Scott Marcus · 2009 to 2026
$9.3M
NCATS NIH HHS UL1 TR002345NIA NIH HHS K01 AG062683NIA NIH HHS K99 AG058780NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS P01 AG052350NIA NIH HHS P30 AG019610NIA NIH HHS P30 AG066444NIA NIH HHS P30 AG066530NIA NIH HHS P50 AG005142NIA NIH HHS P50 AG005681NIA NIH HHS P50 AG016573NIA NIH HHS R00 AG058780NIA NIH HHS R01 AG023084NIA NIH HHS R01 AG031581NIA NIH HHS R01 AG039452NIA NIH HHS R01 AG054434NIA NIH HHS R01 AG055770NIA NIH HHS R01 AG060049NIA NIH HHS R01 AG064228NIBIB NIH HHS R01 EB009352NINDS NIH HHS R01 NS034467NINDS NIH HHS R01 NS090904NINDS NIH HHS R01 NS100459
6 · The paper itself

Abstract

Vascular contributions to dementia and Alzheimer's disease are increasingly recognized

Indexed as

AllelesAlzheimer DiseaseAmyloid beta-PeptidesApolipoprotein E4Blood-Brain BarrierCapillariesCognitive DysfunctionCyclophilin AFemaleHeterozygoteHippocampusHumansMaleMatrix Metalloproteinase 9Parahippocampal GyrusPericytesAmyloid beta-PeptidesApolipoprotein E4Cyclophilin AMatrix Metalloproteinase 9MMP9 protein, humanReceptor, Platelet-Derived Growth Factor betatau Proteins

Identifiers

PMID32376954
PMCPMC7250000

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.