ArticleThorax2020
Frailty after lung transplantation is associated with impaired health-related quality of life and mortality.
Article in Thorax, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Change in frailty status in the 12 months following solid organ transplantation: a systematic review and meta-analysis.Age and ageing · 2025Pooled it
- Gait asymmetry across frailty-status groups in older adults: clinical and biomechanical evidence from 3D gait analysis.Annals of medicine · 2026Article
- Frailty and longitudinal pulmonary function trajectories in lung transplant recipients.Respiratory research · 2026Article
- Deconditioning or biology? Triaging frailty in lung transplant candidates.ERJ open research · 2026Article
- Peri-transplant frailty changes impact survival in interstitial lung diseases.ERJ open research · 2026Article
- Machine learning analysis identifies key predictors of baseline lung allograft dysfunction and increased mortality in lung transplant patients.JHLT open · 2026Article
- Timing of quality of life and lung function changes during the first year following lung transplantation: A multicenter prospective cohort study.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2026Observational
- Frailty Index Predicts Future All-cause Mortality and Quality of Life: A 2-Year Follow-up Study Among Korean Older Adults From a Population-based Cohort Study.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2025Article
- Improvements in Patient-reported Functioning After Lung Transplant Is Associated With Improved Quality of Life and Survival.Transplantation direct · 2025Article
- Advances in pathophysiology and assessment methods of chronic obstructive pulmonary disease with frailty.Chinese medical journal pulmonary and critical care medicine · 2025Review
- Disturbed sleep after lung transplantation is associated with worse patient-reported outcomes and chronic lung allograft dysfunction.JHLT open · 2025Article
- Bone Loss after Solid Organ Transplantation: A Review of Organ-Specific Considerations.Endocrinology and metabolism (Seoul, Korea) · 2024Review
- Disturbed sleep after lung transplantation is associated with worse patient-reported outcomes and chronic lung allograft dysfunction.medRxiv : the preprint server for health sciences · 2024Article
- Immune aging: biological mechanisms, clinical symptoms, and management in lung transplant recipients.Frontiers in transplantation · 2024Review
- Changes in Functional Outcomes After an Inpatient Rehabilitation Program for Solid-Organ Transplant Recipients.Progress in transplantation (Aliso Viejo, Calif.) · 2023Article
- Radiomics of spinal muscles: toward a radiological biomarker for allograft rejection in lung transplant.La Radiologia medica · 2023Article
- Cellular Senescence and Frailty in Transplantation.Current transplantation reports · 2023Article
- Mortality Risks after Two Years in Frail and Pre-Frail Older Adults Admitted to Hospital.Journal of clinical medicine · 2023Article
- Subphenotypes of frailty in lung transplant candidates.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2023Article
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Corrections and comments
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Authors and funding
20 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundLung transplantation and related medications are associated with pathobiological changes that can induce frailty, a state of decreased physiological reserve. Causes of persistent or emergent frailty after lung transplantation, and whether such transplant-related frailty is associated with key outcomes, are unknown.
methodsFrailty and health-related quality of life (HRQL) were prospectively measured repeatedly for up to 3 years after lung transplantation. Frailty, quantified by the Short Physical Performance Battery (SPPB), was tested as a time-dependent binary and continuous predictor. The association of transplant-related frailty with HRQL and mortality was evaluated using mixed effects and Cox regression models, respectively, adjusting for age, sex, ethnicity, diagnosis, and for body mass index and lung function as time-dependent covariates. We tested the association between measures of body composition, malnutrition, renal dysfunction and immunosuppressants on the development of frailty using mixed effects models with time-dependent predictors and lagged frailty outcomes.
resultsAmong 259 adults (56% male; mean age 55.9±12.3 years), transplant-related frailty was associated with lower HRQL. Frailty was also associated with a 2.5-fold higher mortality risk (HR 2.51; 95% CI 1.21 to 5.23). Further, each 1-point worsening in SPPB was associated, on average, with a 13% higher mortality risk (HR 1.13; 95% CI 1.04 to 1.23). Secondarily, we found that sarcopenia, underweight and obesity, malnutrition, and renal dysfunction were associated with the development of frailty after transplant.
conclusionsTransplant-related frailty is associated with lower HRQL and higher mortality in lung recipients. Abnormal body composition, malnutrition and renal dysfunction may contribute to the development of frailty after transplant. Confirming the role of these potential contributors and developing interventions to mitigate frailty may improve lung transplant success.
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