Evidence map›Paper›PMID 32376725›Full record

ArticlePediatrics2020

Coinfection and Other Clinical Characteristics of COVID-19 in Children.

Qin Wu, Yuhan Xing, Lei Shi, Wenjie Li, Yang Gao, Silin Pan, Ying Wang, Wendi Wang, Quansheng Xing

Abstract read
PubMed Publisher
In one paragraph

Article in Pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed, 16 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

123 citing papers in PubMed, 16 syntheses or guidelines pooled it.

  1. Pooled it
  2. Systematic review with meta-analysis of active herpesvirus infections in patients with COVID-19: Old players on the new field.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2023
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63 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Qin WuQingdao Women and Children's Hospital of Qingdao University, Qingdao, China.
Yuhan XingDepartment of Pediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; and xingqs0532@163.com.
Lei ShiQingdao Women and Children's Hospital of Qingdao University, Qingdao, China.
Wenjie LiQingdao Women and Children's Hospital of Qingdao University, Qingdao, China.
Yang GaoQingdao Women and Children's Hospital of Qingdao University, Qingdao, China.
Silin PanQingdao Women and Children's Hospital of Qingdao University, Qingdao, China.
Ying WangWuhan Children's Hospital and Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wendi WangQingdao Women and Children's Hospital of Qingdao University, Qingdao, China.
Quansheng XingQingdao Women and Children's Hospital of Qingdao University, Qingdao, China; xingqs0532@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly identified pathogen that mainly spreads by droplets. Most published studies have been focused on adult patients with coronavirus disease 2019 (COVID-19), but data concerning pediatric patients are limited. In this study, we aimed to determine epidemiological characteristics and clinical features of pediatric patients with COVID-19.

methodsWe reviewed and analyzed data on pediatric patients with laboratory-confirmed COVID-19, including basic information, epidemiological history, clinical manifestations, laboratory and radiologic findings, treatment, outcome, and follow-up results.

resultsA total of 74 pediatric patients with COVID-19 were included in this study. Of the 68 case patients whose epidemiological data were complete, 65 (65 of 68; 95.59%) were household contacts of adults. Cough (32.43%) and fever (27.03%) were the predominant symptoms of 44 (59.46%) symptomatic patients at onset of the illness. Abnormalities in leukocyte count were found in 23 (31.08%) children, and 10 (13.51%) children presented with abnormal lymphocyte count. Of the 34 (45.95%) patients who had nucleic acid testing results for common respiratory pathogens, 19 (51.35%) showed coinfection with other pathogens other than SARS-CoV-2. Ten (13.51%) children had real-time reverse transcription polymerase chain reaction analysis for fecal specimens, and 8 of them showed prolonged existence of SARS-CoV-2 RNA.

conclusionsPediatric patients with COVID-19 presented with distinct epidemiological, clinical, and radiologic characteristics from adult patients. Nearly one-half of the infected children had coinfection with other common respiratory pathogens. It is not uncommon for pediatric patients to have prolonged fecal shedding of SARS-CoV-2 RNA during the convalescent phase.

Indexed as

BetacoronavirusChildChild, PreschoolChinaCoinfectionCoronavirus InfectionsCOVID-19FemaleFollow-Up StudiesHospitalizationHumansInfantMalePandemicsPneumonia, ViralRetrospective Studies

Identifiers

PMID32376725

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.