Evidence map›Paper›PMID 32376563›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2020

[Expressions of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinases 1 in skeletal muscles of aged rats with sarcopenia].

Shiyu Zhu, Ankang Lü, Yuxing Zhao, Die Pu, Zhiyin Liao, Yue Sun, Jinliang Chen, Qian Xiao

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Shiyu ZhuDepartment of Geriatrics, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Ankang LüDepartment of Geriatrics, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Yuxing ZhaoDepartment of Geriatrics, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Die PuDepartment of Geriatrics, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Zhiyin LiaoDepartment of Geriatrics, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Yue SunDepartment of Geriatrics, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Jinliang ChenDepartment of Geriatrics, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Qian XiaoDepartment of Geriatrics, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
First Affiliated Hospital of Chongqing Medical University · CNChongqing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the changes of skeletal muscle mass and strength and the expressions of matrix metalloproteinase-1 (MMP-1), tissue inhibitor of metalloproteinases-1 (TIMP-1) and collagen-1 in the skeletal muscle of aged rats with sarcopenia.

methodsWith 11 young (6-month-old) SD rats as control group, 18 aged (25-month-old) SD rats were divided into two groups (n=9) according to the relative lean mass determined dual X-ray absorptiometry (DXA), namely aged control group and aged sarcopenia group (the relative lean mass was 2SD higher in aged control than in aged sarcopenia group. The forelimb grip strength of the rats was measured using an electronic grip strength meter. The extracellular matrix (ECM) of the rat's gastrocnemius was observed with HE staining and sirius Red staining, and the protein expressions of collagen-1, MMP-1, and TIMP-1 in the muscular tissues were detected with Western blotting.

resultsCompared with the young rats, the aged control rats had significantly lower relative grip strength (

conclusionsMMP-1/TIMP-1 imbalance in the skeletal muscle during aging affects ECM metabolism and leads to increased collagen fibers, which in turn affects the skeletal muscle mass and function and contribute to the onset of sarcopenia.

Indexed as

AgingAnimalsMatrix Metalloproteinase 1Matrix Metalloproteinase 13Muscle, SkeletalRatsRats, Sprague-DawleySarcopeniaTissue Inhibitor of Metalloproteinase-1Matrix Metalloproteinase 1Matrix Metalloproteinase 13MMP1 protein, ratTIMP1 protein, ratTissue Inhibitor of Metalloproteinase-1extracellular matrixmatrix metalloproteinase-1sarcopeniatissue inhibitor of metalloproteinases-1

Identifiers

PMID32376563
PMCPMC7040751
OpenAlexW3009800687

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.