ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2020
[Analysis of variation and evolution of SARS-CoV-2 genome].
Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review and meta-analysis of the efficacy and safety of arbidol in the treatment of coronavirus disease 2019.Medicine · 2020Pooled it
- Extracellular Vesicle-Based SARS-CoV-2 Vaccine.Vaccines · 2023Review
- SARS-CoV-2 and natural infection in animals.Journal of medical virology · 2023Review
- Genomic and structural mechanistic insight to reveal the differential infectivity of omicron and other variants of concern.Computers in biology and medicine · 2022Article
- Article
- Bioinformatics Accelerates the Major Tetrad: A Real Boost for the Pharmaceutical Industry.International journal of molecular sciences · 2021Review
- Review
- Genome-wide identification of the histone acetyltransferase gene family in Triticum aestivum.BMC genomics · 2021Article
- [Progress in source tracking of SARS-CoV-2].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Article
- [A systematic pharmacological investigation of pharmacologically active ingredients in Toujie Quwen granules for treatment of COVID-19].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Article
- Clinical and radiological features of novel coronavirus pneumonia.Journal of X-ray science and technology · 2020Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo analyze the evolution and variation of SARS-CoV-2 during the epidemic starting at the end of 2019.
methodsWe downloaded the full-length genome sequence of SARS-CoV-2 from the databases of GISAID and NCBI. Using the software for bioinformatics including MEGA-X, BEAST, and TempEst, we constructed the genomic evolution tree, inferred the time evolution signal of the virus, calculated the tMRCA time of the virus and analyzed the selection pressure of the virus during evolution.
resultsThe phylogenetic tree showed that SARS-CoV-2 belonged to the Sarbecovirus subgenus of β Coronavirus genus together with bat coronavirus BetaCoV/bat/Yunnan/RaTG13/2013, bat-SL-CoVZC45, bat-SL-CoVZXC21 and SARS-CoV. The genomic sequences of SARS-CoV-2 isolated from the ongoing epidemic showed a weak time evolution signal with an average tMRCA time of 73 days (95% CI: 38.9-119.3 days). No positive time evolution signal was found between SARS-CoV-2 and BetaCoV/bat/Yunnan/RaTG13/2013, but the former virus had a strong positive temporal evolution relationship with bat-SL-CoVZC45 and SARS-CoV. The major cause for mutations of SARS-CoV-2 was the pressure of purification selection during the epidemic.
conclusionsSARS-CoV-2 may have emerged as early as November, 2019, originating most likely from bat-associated coronavirus. This finding may provide evidence for tracing the sources and evolution of the virus.
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