Evidence map›Paper›PMID 32376461›Full record

ArticleJournal of controlled release : official journal of the Controlled Release Society2020

Focused ultrasound blood brain barrier opening mediated delivery of MRI-visible albumin nanoclusters to the rat brain for localized drug delivery with temporal control.

Megan C Rich, Jennifer Sherwood, Aundrea F Bartley, Quentin A Whitsitt, Magdelene Lee, W R Willoughby, Lynn E Dobrunz, Yuping Bao, Farah D Lubin, Mark Bolding

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of controlled release : official journal of the Controlled Release Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Mechanotransduction Activates Microglia and Impairs Phagocytosis in Stiff Amyloid-β Plaques.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  5. Review
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  7. Review
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  11. Drug delivery to the central nervous system.Nature reviews. Materials · 2022
    Article
  12. Article
  13. Article
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Megan C RichDepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address: mcrich@uab.edu.
Jennifer SherwoodDepartment of Chemical and Biological Engineering, University of Alabama at Tuscaloosa, Tuscaloosa, AL 35487, USA.
Aundrea F BartleyDepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address: abartley@uab.edu.
Quentin A WhitsittDepartment of Radiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Magdelene LeeDepartment of Chemical and Biological Engineering, University of Alabama at Tuscaloosa, Tuscaloosa, AL 35487, USA.
W R WilloughbyDepartment of Radiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address: wwilloughby@uab.edu.
Lynn E DobrunzDepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address: dobrunz@uab.edu.
Yuping BaoDepartment of Chemical and Biological Engineering, University of Alabama at Tuscaloosa, Tuscaloosa, AL 35487, USA. Electronic address: ybao@eng.ua.edu.
Farah D LubinDepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address: flubin@uab.edu.
Mark BoldingDepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA; Department of Radiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address: mbolding@uab.edu.
University of Alabama at Birmingham · USUniversity of Alabama · US

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
Visual Phenotyping CoreP30EY003039 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul Douglas Gamlin · 1985 to 2026
$16.9M
NCI NIH HHS P30 CA013148NEI NIH HHS P30 EY003039
6 · The paper itself

Abstract

There is an ongoing need for noninvasive tools to manipulate brain activity with molecular, spatial and temporal specificity. Here we have investigated the use of MRI-visible, albumin-based nanoclusters for noninvasive, localized and temporally specific drug delivery to the rat brain. We demonstrated that IV injected nanoclusters could be deposited into target brain regions via focused ultrasound facilitated blood brain barrier opening. We showed that nanocluster location could be confirmed in vivo with MRI. Additionally, following confirmation of nanocluster delivery, release of the nanocluster payload into brain tissue can be triggered by a second focused ultrasound treatment performed without circulating microbubbles. Release of glutamate from nanoclusters in vivo caused enhanced c-Fos expression, indicating that the loading capacity of the nanoclusters is sufficient to induce neuronal activation. This novel technique for noninvasive stereotactic drug delivery to the brain with temporal specificity could provide a new way to study brain circuits in vivo preclinically with high relevance for clinical translation.

Indexed as

Blood-Brain BarrierPharmaceutical PreparationsAlbuminsAnimalsBrainDrug Delivery SystemsMagnetic Resonance ImagingMicrobubblesRatsAlbuminsPharmaceutical PreparationsAlbumin drug carriersBlood brain barrierBlood brain barrier disruptionDrug-deliveryFocused ultrasoundFocused ultrasound blood brain barrier openingImage-guided drug deliveryMRI-guided drug deliveryNanoclustersNoninvasive neuromodulation

Identifiers

PMID32376461
PMCPMC8890744
OpenAlexW3023763970

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.