ReviewJournal of molecular biology2020
Circadian and Sleep Metabolomics Across Species.
Review in Journal of molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 52 citations in OpenAlex.
- The clock gene cycle synchronizes circadian metabolic oscillations uniquely in reproductively active Culex pipiens females.npj metabolic health and disease · 2026Article
- Circadian clocka regulates the zebrafish central neuronal Mauthner-cell axon regeneration via phosphodiesterase family pde4a.NPJ Regenerative medicine · 2026Article
- The association of night shift work with the risk of acute ischemic cerebrovascular syndrome: a longitudinal study of 204,261 UK Biobank participants.Journal of neurology · 2026Article
- Glucose is dynamically regulated by time of day in humans and Drosophila.PLoS biology · 2026Article
- Pink noise reduces impact of traffic noise on sleep and the blood metabolome: a cross-over pilot study.Communications medicine · 2026Article
- Causal relations of trace elements and nutrients with insomnia: A Mendelian randomization study.Medicine · 2025Article
- Integrating Advanced Metabolomics and Machine Learning for Anti-Doping in Human Athletes.Metabolites · 2025Review
- Comparative Analysis of the Daily Liver Metabolomics of Asian Particolored Bat.Ecology and evolution · 2025Article
- A carnitine transporter at the blood-brain barrier modulates sleep via glial lipid metabolism inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Nitrogen waste metabolism as a locus of nitrergic co-transmission in the brain.Frontiers in behavioral neuroscience · 2025Review
- Balancing brain metabolic states during sickness and recovery sleep.The European journal of neuroscience · 2024Article
- Altered Metabolism during the Dark Period in Drosophila Short Sleep Mutants.Journal of proteome research · 2024Article
- Glucose Challenge Uncovers Temporal Fungibility of Metabolic Homeostasis over a day:night cycle.bioRxiv : the preprint server for biology · 2024Article
- The interplay between sleep and ecophysiology, behaviour and responses to environmental change in fish.The Journal of experimental biology · 2024Review
- Time-of-day-dependent variation of the human liver transcriptome and metabolome is disrupted in MASLD.JHEP reports : innovation in hepatology · 2024Article
- Human serum proteomics reveals a molecular signature after one night of sleep deprivation.Sleep advances : a journal of the Sleep Research Society · 2024Article
- Day-night fluctuations in choroid plexus transcriptomics and cerebrospinal fluid metabolomics.PNAS nexus · 2023Article
- Chronic sleep loss sensitizes Drosophila melanogaster to nitrogen stress.Current biology : CB · 2023Article
- Article
- Do macrophages follow the beat of circadian rhythm in TIME (Tumor Immune Microenvironment)?F1000Research · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Under normal circadian function, metabolic control is temporally coordinated across tissues and behaviors with a 24-h period. However, circadian disruption results in negative consequences for metabolic homeostasis including energy or redox imbalances. Yet, circadian disruption has become increasingly prevalent within today's society due to many factors including sleep loss. Metabolic consequences of both have been revealed by metabolomics analyses of circadian biology and sleep. Specifically, two primary analytical platforms, mass spectrometry and nuclear magnetic resonance spectroscopy, have been used to study molecular clock and sleep influences on overall metabolic rhythmicity. For example, human studies have demonstrated the prevalence of metabolic rhythms in human biology, as well as pan-metabolome consequences of sleep disruption. However, human studies are limited to peripheral metabolic readouts primarily through minimally invasive procedures. For further tissue- and organism-specific investigations, a number of model systems have been studied, based upon the conserved nature of both the molecular clock and sleep across species. Here we summarize human studies as well as key findings from metabolomics studies using mice, Drosophila, and zebrafish. While informative, a limitation in existing literature is a lack of interpretation regarding dynamic synthesis or catabolism within metabolite pools. To this extent, future work incorporating isotope tracers, specific metabolite reporters, and single-cell metabolomics may provide a means of exploring dynamic activity in pathways of interest.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.