ArticleNeuroImage2020
Neural correlates of working memory training: Evidence for plasticity in older adults.
Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Cognition, body, and mind: A three-in-one coordinate-based fMRI meta-analysis on cognitive, physical, and meditative trainings.Human brain mapping · 2023Pooled it
- Feasibility of Gamified EEG Neurofeedback Combined with Adaptive Working-Memory Training in Older Adults: A Pilot Study.Brain sciences · 2026Article
- Neural Compensation in the Medial Prefrontal Cortex Preserves Self-Prioritization in Aging: A Computational Approach.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Adaptive visuospatial n-back training improves audiovisual integration and executive control in older adults.Frontiers in psychology · 2026Article
- Effective Motor Skill Learning Induces Inverted-U Load-Dependent Activation in Contralateral Pre-Motor and Supplementary Motor Area.Human brain mapping · 2025Article
- Is working memory domain-general or domain-specific?Trends in cognitive sciences · 2024Review
- Brain activations elicited during task-switching generalize beyond the task: A partial least squares correlation approach to combine fMRI signals and cognition.Human brain mapping · 2024Article
- Effects and mechanisms of computerized cognitive training in Huntington's disease: protocol for a pilot study.Neurodegenerative disease management · 2024Article
- Don't forget the little brain: A framework for incorporating the cerebellum into the understanding of cognitive aging.Neuroscience and biobehavioral reviews · 2022Review
- Longitudinal MRI-visible perivascular space (PVS) changes with long-duration spaceflight.Scientific reports · 2022Article
- Age differences in functional network reconfiguration with working memory training.Human brain mapping · 2021Article
- Independent Contributions of Dorsolateral Prefrontal Structure and Function to Working Memory in Healthy Older Adults.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Effects of multi-domain cognitive training on working memory retrieval in older adults: behavioral and ERP evidence from a Chinese community study.Scientific reports · 2021Article
- Working Memory Training and Cortical Arousal in Healthy Older Adults: A Resting-State EEG Pilot Study.Frontiers in aging neuroscience · 2021Article
- Different Modulatory Effects of Cognitive Training and Aerobic Exercise on Resting State Functional Connectivity of Entorhinal Cortex in Community-Dwelling Older Adults.Frontiers in aging neuroscience · 2021Article
- Cognitive Tele-Enhancement in Healthy Older Adults and Subjects With Subjective Memory Complaints: A Review.Frontiers in neurology · 2021Review
- Obstacle Negotiation in Older Adults: Prefrontal Activation Interpreted Through Conceptual Models of Brain Aging.Innovation in aging · 2020Article
- Cognitive training and retest learning effects on theta and alpha power in older and young adults: A perspective on the crunch hypothesis and the STAC-R model.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
Brain activity typically increases with increasing working memory (WM) load, regardless of age, before reaching an apparent ceiling. However, older adults exhibit greater brain activity and reach ceiling at lower loads than younger adults, possibly reflecting compensation at lower loads and dysfunction at higher loads. We hypothesized that WM training would bolster neural efficiency, such that the activation peak would shift towards higher memory loads after training. Pre-training, older adults showed greater recruitment of the WM network than younger adults across all loads, with decline at the highest load. Ten days of adaptive training on a verbal WM task improved performance and led to greater brain responsiveness at higher loads for both groups. For older adults the activation peak shifted rightward towards higher loads. Finally, training increased task-related functional connectivity in older adults, both within the WM network and between this task-positive network and the task-negative/default-mode network. These results provide new evidence for functional plasticity with training in older adults and identify a potential signature of improvement at the neural level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.