Trial reportThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2020
Resting State Functional Connectivity and Outcomes of Psychotherapies for Late-Life Depression.
Trial report in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Social reward processing in depressed and healthy individuals across the lifespan: A systematic review and a preliminary coordinate-based meta-analysis of fMRI studies.Behavioural brain research · 2023Pooled it
- Strength-based methods - a narrative review and comparative multilevel meta-analysis of positive interventions in clinical settings.Psychotherapy research : journal of the Society for Psychotherapy Research · 2023Pooled it
- Brain Activation Associated With Response to Psychotherapies for Late-Life Depression: A Task-Based fMRI Study.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2025Trial
- Targeting mechanisms of change as a path to precision psychotherapy for community settings.Psychotherapy research : journal of the Society for Psychotherapy Research · 2026Article
- Moderators of treatment response in late-life depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Engage & connect psychotherapy improves social reward responsivity and reduces postpartum depression.Psychotherapy research : journal of the Society for Psychotherapy Research · 2025Article
- Ventral striatal-cingulate resting-state functional connectivity in healthy adolescents relates to later depression symptoms in adulthood.Journal of affective disorders · 2024Article
- Improving social reward responsivity and social connectedness in psychotherapies for late-life depression: Engage & Connect as an example.Psychiatry research · 2023Article
- The heterogeneity of late-life depression and its pathobiology: a brain network dysfunction disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2023Review
- Brain morphometric features predict depression symptom phenotypes in late-life depression using a deep learning model.Frontiers in neuroscience · 2023Article
- Rostral anterior cingulate connectivity in older adults with subthreshold depressive symptoms: A preliminary study.Aging brain · 2023Article
- Improving Interventions for Loneliness and Social Isolation in Late Life: The Potential Role of Positive Affect.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2022Article
- Altered voxel-level whole-brain functional connectivity in multiple system atrophy patients with depression symptoms.BMC psychiatry · 2022Article
- Low-dissipation optimization of the prefrontal cortex in the -12° head-down tilt position: A functional near-infrared spectroscopy study.Frontiers in psychology · 2022Article
- Abnormal Functional Connectivity of Hippocampal Subdivisions in Obstructive Sleep Apnea: A Resting-State Functional Magnetic Resonance Imaging Study.Frontiers in neuroscience · 2022Article
- Enhanced Resting-State Functional Connectivity of the Nucleus Accumbens in First-Episode, Medication-Naïve Patients With Early Onset Schizophrenia.Frontiers in neuroscience · 2022Article
- Connectivity patterns of the core resting-state networks associated with apathy in late-life depression.Journal of psychiatry & neuroscience : JPNArticle
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 2 countries.
Funding
Abstract
backgroundProblem solving therapy (PST) and "Engage," a reward-exposure" based therapy, are important treatment options for late-life depression, given modest efficacy of antidepressants in this disorder. Abnormal function of the reward and default mode networks has been observed during depressive episodes. This study examined whether resting state functional connectivity (rsFC) of reward and DMN circuitries is associated with treatment outcomes.
methodsThirty-two older adults with major depression (mean age = 72.7) were randomized to 9-weeks of either PST or "Engage." We assessed rsFC at baseline and week 6. We placed seeds in three a priori regions of interest: subgenual anterior cingulate cortex (sgACC), dorsal anterior cingulate cortex (dACC), and nucleus accumbens (NAcc). Outcome measures included the Hamilton Depression Rating Scale (HAMD) and the Behavioral Activation for Depression Scale (BADS).
resultsIn both PST and "Engage," higher rsFC between the sgACC and middle temporal gyrus at baseline was associated with greater improvement in depression severity (HAMD). Preliminary findings suggested that in "Engage" treated participants, lower rsFC between the dACC and dorsomedial prefrontal cortex at baseline was associated with HAMD improvement. Finally, in Engage only, increased rsFC from baseline to week 6 between NAcc and Superior Parietal Cortex was associated with increased BADS scores.
conclusionThe results suggest that patients who present with higher rsFC between the sgACC and a structure within the DMN may benefit from behavioral psychotherapies for late life depression. "Engage" may lead to increased rsFC within the reward system reflecting a reconditioning of the reward systems by reward exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.