Evidence map›Paper›PMID 32375913›Full record

ArticleJournal of the International Neuropsychological Society : JINS2020

REM Sleep Behavior Disorder in Parkinson's Disease: Effects on Cognitive, Psychiatric, and Functional outcomes.

Zanjbeel Mahmood, Ryan Van Patten, Marina Z Nakhla, Elizabeth W Twamley, J Vincent Filoteo, Dawn M Schiehser

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the International Neuropsychological Society : JINS, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07498452 (Exploring Unmet Needs Among Patients With Isolated REM Sleep Behavior Disorder), which is not on this map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
1.7field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07498452 recruitingnot on this mapstarted 2025, after this paper: background citation

Exploring Unmet Needs Among Patients With Isolated REM Sleep Behavior Disorder (iRBD) and Their Significant Others: A Multicenter Cross-Sectional Survey Study

TypeobservationalSponsorUniversita di VeronaRan2025 to 2026Enrolled150ConditionsREM Sleep Behavior Disorder, Isolated REM Sleep Behavior Disorder
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. The effect of Gua Sha therapy on Parkinson's disease with rapid eye movement sleep behavior disorder: a randomized controlled trial.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Trial
  5. Review
  6. Review
  7. Prevalence of Probable REM Sleep Behavior Disorder in Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026
    Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. REM Sleep Behavior Disorder in Parkinson's Disease: Change in Cognitive, Psychiatric, and Functional Outcomes from Baseline to 16-47-Month Follow-Up.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Zanjbeel MahmoodSDSU/UC San Diego Joint Doctoral Program in Clinical Psychology, 6363 Alvarado Ct, San Diego, CA, USA.ORCID 0000-0003-1979-4077
Ryan Van PattenResearch Service, VA San Diego Healthcare System, 3350 La Jolla Village Dr., San Diego, CA92161, USA.
Marina Z NakhlaSDSU/UC San Diego Joint Doctoral Program in Clinical Psychology, 6363 Alvarado Ct, San Diego, CA, USA.
Elizabeth W TwamleyResearch Service, VA San Diego Healthcare System, 3350 La Jolla Village Dr., San Diego, CA92161, USA.
J Vincent FiloteoResearch Service, VA San Diego Healthcare System, 3350 La Jolla Village Dr., San Diego, CA92161, USA.
Dawn M SchiehserResearch Service, VA San Diego Healthcare System, 3350 La Jolla Village Dr., San Diego, CA92161, USA.
University of California San Diego · USSan Diego State University · US

Funding

FELLOWSHIP IN GERIATRIC MENTAL HEALTHT32MH019934 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Elizabeth W Twamley · 1994 to 2026
$9.5M
Novel Predictors of Cognitive and Psychiatric Change in Parkinson's DiseaseI01CX000813 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI FILOTEO, J. VINCENT · 2013 to 2016
–
CSRD VA I01 CX000813NIMH NIH HHS T32 MH019934RRD VA I01 RX001691RRD VA IK6 RX003504
6 · The paper itself

Abstract

objectiveRapid eye movement sleep behavior disorder (RBD) affects 33-46% of patients with Parkinson's disease (PD) and may be a risk factor for neuropsychological and functional deficits. However, the role of RBD on neuropsychological functioning in PD has yet to be fully determined. We, therefore, examined differences in neurocognitive performance, functional capacity, and psychiatric symptoms among nondemented PD patients with probable RBD (PD/pRBD+) and without (PD/pRBD-), and healthy comparison participants (HC).

methodsTotally, 172 participants (58 PD/pRBD+; 65 PD/pRBD-; 49 HC) completed an RBD sleep questionnaire, psychiatric/clinical questionnaires, performance-based and self-reported functional capacity measures, and underwent a comprehensive neuropsychological battery assessing attention/working memory, language, visuospatial function, verbal and visual learning and memory, and executive function.

resultsControlling for psychiatric symptom severity, the PD/pRBD+ group had poorer executive functioning and learning performance than the PD/pRBD- group and poorer neuropsychological functioning across all individual cognitive domains than the HCs. In contrast, PD/pRBD- patients had significantly lower scores than HCs only in the language domain. Moreover, PD/pRBD+ patients demonstrated significantly poorer medication management skills compared to HCs. Both PD groups reported greater depressive and anxiety severity compared to HCs; PD/pRBD+ group also endorsed greater severity of apathy compared to HCs.

conclusionsThe presence of pRBD is associated with poorer neuropsychological functioning in PD such that PD patients with pRBD have poorer cognitive, functional, and emotional outcomes compared to HC participants and/or PD patients without pRBD. Our findings underscore the importance of RBD assessment for improved detection and treatment of neuropsychological deficits (e.g., targeted cognitive interventions).

Indexed as

AgedAttentionCognitionCognitive DysfunctionExecutive FunctionFemaleHumansLanguageMaleMiddle AgedNeuropsychological TestsParkinson DiseaseREM Sleep Behavior DisorderRisk FactorsSurveys and QuestionnairesApathyCognitionExecutive functioningFunctional capacityLearningNeuropsychology

Identifiers

PMID32375913
PMCPMC7554050
OpenAlexW3022802800

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.